September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Retrograde Differentiation of Retinoblastoma in Infants
Author Affiliations & Notes
  • Ananth Sastry
    Ophthalmology, USC Eye Institute, Los Angeles, California, United States
  • Hassan A Aziz
    Ophthalmology, USC Eye Institute, Los Angeles, California, United States
  • Jesse L Berry
    Ophthalmology, USC Eye Institute, Los Angeles, California, United States
  • Jonathan W Kim
    Ophthalmology, USC Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Ananth Sastry, None; Hassan Aziz, None; Jesse Berry, None; Jonathan Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3674. doi:
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    • Get Citation

      Ananth Sastry, Hassan A Aziz, Jesse L Berry, Jonathan W Kim; Retrograde Differentiation of Retinoblastoma in Infants. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3674.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the development of new posteriorly located retinoblastoma tumors in the absence of seeding in two infants who had been treated previously for a macular tumor.

Methods : Case Series

Results : Two young children were diagnosed with bilateral retinoblastoma and treated with systemic chemotherapy for the more advanced Group B eye. Focal laser consolidation was given to treat a macular tumor in both eyes. Several months after establishing control over the macular tumor a non-contiguous nodule was noted adjacent the optic nerve. This nodule was seen in the absence of seeding or new subretinal fluid. Additionally both patients had more peripheral tumors in the eye before the development of the optic nerve nodule. Both nodules exhibited growth and were thus treated successfully with focal modalities.

Conclusions : A commonly held doctrine in retinal differentiation is the development from the fovea peripherally. This correlates clinically with retinoblastoma tumors developing centrally in younger patients and peripherally in older children. This case reports described two children who developed a new multifocal tumor adjacent the optic nerve in the absence of significant subretinal fluid or seeding. Both children had developed a peripheral, anterior tumor before the diagnosis of the peripapillary tumor.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

 

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