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Ananth Sastry, Hassan A Aziz, Jesse L Berry, Jonathan W Kim; Retrograde Differentiation of Retinoblastoma in Infants. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3674.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the development of new posteriorly located retinoblastoma tumors in the absence of seeding in two infants who had been treated previously for a macular tumor.
Two young children were diagnosed with bilateral retinoblastoma and treated with systemic chemotherapy for the more advanced Group B eye. Focal laser consolidation was given to treat a macular tumor in both eyes. Several months after establishing control over the macular tumor a non-contiguous nodule was noted adjacent the optic nerve. This nodule was seen in the absence of seeding or new subretinal fluid. Additionally both patients had more peripheral tumors in the eye before the development of the optic nerve nodule. Both nodules exhibited growth and were thus treated successfully with focal modalities.
A commonly held doctrine in retinal differentiation is the development from the fovea peripherally. This correlates clinically with retinoblastoma tumors developing centrally in younger patients and peripherally in older children. This case reports described two children who developed a new multifocal tumor adjacent the optic nerve in the absence of significant subretinal fluid or seeding. Both children had developed a peripheral, anterior tumor before the diagnosis of the peripapillary tumor.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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