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Robert Wanzek, Eric Lee, Trina Eden, Andrew Turpin, Luke Chong, Michael Wall; Depth of Visual Field Loss Using Threshold Automated Perimetry Increases with Eccentricity in Glaucoma Subjects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3899.
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© ARVO (1962-2015); The Authors (2016-present)
The visual field outside 30 degrees has not been systematically explored using static automated perimetry. We performed a cross-sectional clinical study to characterize differences in the full visual field between glaucoma and control subjects.
We gave 11 early stage glaucoma patients (less than -4 dB mean deviation) ages 58-74 and 63 controls ages 18-78, 30-2 Size V and Peripheral Size V tests using the Octopus 900 perimeter running the OPI (Open Perimetry Interface) with code our lab has developed. We repeated the tests at a second visit completed within a month of the first. Test locations of similar distance from fixation were grouped into eccentricity zones, each with roughly the same number of test locations. Thresholds within a zone were averaged and a slope and intercept were calculated for each subject. We then calculated the average slope for both glaucoma subjects and controls and compared them using statistical tests.
The graph shows the decrease in visual sensitivity with eccentricity. This effect is more pronounced in the glaucoma patients (orange symbols and line). Due to unequal variances, a rank-sum test was performed to test for differences in these slopes and a statistically significant (p < .001) difference in the slopes between glaucoma patients and controls was found.
While all subjects show sensitivity loss with eccentricity, our new finding is that glaucoma patients demonstrate a greater linear decrease in sensitivity with eccentricity.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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