September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal Ocular Photosensitivity Assessment of Healthy and Achromatopsic Subjects
Author Affiliations & Notes
  • Mariela C Aguilar
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Ergonomics and Human Factors, Department of Industrial Engineering, College of Engineering, University of Miami, Coral Gables, Florida, United States
  • Alex Gonzalez
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Cornelis Rowaan
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Carolina P De Freitas
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Karam AlRahman Alawa
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Heather Ann Durkee
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Alejandro Arboleda
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Florence Cabot
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Potyra R Rosa
    Anne Bates Leach Eye Hospital, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Byron L Lam
    Anne Bates Leach Eye Hospital, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute, UNSW, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Mariela Aguilar, None; Alex Gonzalez, None; Cornelis Rowaan, None; Carolina De Freitas, None; Karam Alawa, None; Heather Durkee, None; Alejandro Arboleda, None; Florence Cabot, None; Potyra Rosa, None; Byron Lam, None; Jean-Marie Parel, None
  • Footnotes
    Support  Supported in part by: NEI Grant R24 EY022023, DOD Grant DAMD-W81XWH-09-1-0675 and DOD Warfighters Grant W81XWH-13-1-0048, Florida Lions Eye Bank, Drs. KR Olsen and ME Hildebrandt, Drs. Raksha Urs and Aaron Furtado, Brien Holden Vision Institute, NIH Center Grant P30EY14801, Research to Prevent Blindness, Henri and Flore Lesieur Foundation (JMP). Technical support provided by: Fabrice Manns, David H. Sliney, Andres Bernal, Varona Sargent, William Lee, Juan Silgado, Nelson Salas, Nidhi Relhan, and William J. Feuer.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 622. doi:
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    • Get Citation

      Mariela C Aguilar, Alex Gonzalez, Cornelis Rowaan, Carolina P De Freitas, Karam AlRahman Alawa, Heather Ann Durkee, Alejandro Arboleda, Florence Cabot, Potyra R Rosa, Byron L Lam, Jean-Marie A Parel; Longitudinal Ocular Photosensitivity Assessment of Healthy and Achromatopsic Subjects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):622.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Achromatopsia is a genetic disorder characterized by decreased vision, discomfort when exposed to light, and an inability to differentiate color. The purpose of this study was to determine the stability and reliability of the Ocular Photosensitivity Analyzer (OPA) using healthy subjects over time and whether there is a significant change in photosensitivity thresholds over time in achromatopsic subjects.

Methods : The OPA generates a light stimulus using 210 white LEDs mounted on a bi-cupola concave surface providing varying light intensity in logarithmic ascending and descending steps ranging from 0 to 4.51 log(lux) (1 to 32,000 lux). The subject is instructed to indicate whether the light stimulus is uncomfortable by pressing a hand-held button and the photosensitivity threshold is calculated after 10 response reversals. Catch trials were programmed into the OPA software to ensure the subjects’ response reliability throughout the test. Power output and irradiance were measured to ensure the OPA meets safety exposure limits set forth by the ISO standard for ophthalmic instruments.

Nine healthy (5 females and 4 males, age = 31.4±7.6 years) and four achromatopsic subjects (2 females and 2 males, age = 10.5±4.4 years) were tested under an IRB approved protocol. Photosensitivity of healthy and achromatopsic subjects were measured at 0, 2, 12, 40, and 379 days and at 0, 6 and 12 months, respectively. A one-way analysis of variance was performed within each of the subject groups to determine significance in the photosensitivity thresholds between time points.

Results : The mean photosensitivity threshold up to 379 days for healthy subjects was 3.27±0.13 log(lux). No significant change was noted for healthy subjects (p=0.98), demonstrating the reliability of the OPA. The mean photosensitivity threshold between 0 and 12 months for achromatopsic subjects was 0.48±0.52 log(lux). Despite the larger standard deviation, the change in the photosensitivity thresholds for achromatopsic subjects was not significant (p= 0.71) within 12 months.

Conclusions : The OPA is a safe and reliable instrument to perform longitudinal determinations of the photosensitivity thresholds in subjects. Healthy and achromatopsic subjects demonstrated no significant change in photosensitivity thresholds at varying time points. Ongoing studies are being performed with this system to increase our subject population and further validate our findings.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

 

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