September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
OCT Biometry of the Crystalline Lens during Dynamic Accommodation
Author Affiliations & Notes
  • Siobhan Williams
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, Florida, United States
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, Florida, United States
  • Giovanni Gregori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Yu-Cherng Chang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, Florida, United States
  • Sonia H Yoo
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Vision Cooperative Research Centre, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Siobhan Williams, None; Marco Ruggeri, US8425037 B2 (P); Fabrice Manns, US8425037 B2 (P); Giovanni Gregori, Carl Zeiss Meditec (F); Yu-Cherng Chang, None; Sonia Yoo, None; Jean-Marie Parel, US8425037 B2 (P)
  • Footnotes
    Support  NIH R01EY14225, RO1EY021834, P30EY14801; Australian Government CRC Scheme (Vision CRC); Florida Lions Eye Bank; Research to Prevent Blindness; Drs. KR Olsen and ME Hildebrandt, Drs. Raksha Urs and Aaron Furtado; Henri and Flore Lesieur Foundation (JMP).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3959. doi:
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    • Get Citation

      Siobhan Williams, Marco Ruggeri, Fabrice Manns, Giovanni Gregori, Yu-Cherng Chang, Sonia H Yoo, Jean-Marie A Parel; OCT Biometry of the Crystalline Lens during Dynamic Accommodation. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3959.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify changes in crystalline lens thickness and radii of curvature during dynamic accommodation using extended depth OCT.

Methods : In-vivo responses to an accommodative step stimulus of three subjects (aged 22, 39, and 45) were captured using a custom-made extended-depth SD-OCT system operating at 840nm following an IRB-approved protocol. The OCT system produced images of the entire anterior segment from the anterior cornea to the posterior lens with a frame rate of 13Hz (Ruggeri et al, Biomed Opt Exp, 2012). During imaging, subjects focused on a visual accommodation target designed to produce an adjustable step stimulus of accommodation. Accommodative responses to a 2D and 4D stimulus were measured. Each image in the sequence was segmented using a custom-developed automated algorithm that exploits derivative and intensity image cues to localize the corneal and lens boundaries. The segmented corneal and lens contours were corrected for refractive distortions. Radius of curvature was determined by fitting the central 6mm of each distortion corrected contour with a conic curve. Values of lens thickness and curvature in the relaxed and accommodated states were calculated by averaging values before and after the stimulus was applied. The dynamic changes in lens thickness and curvature were fit with an exponential model to produce time dependent constants.

Results : Results are summarized in Table 1. Anterior lens radius decreased over time in all subjects. Posterior lens curvature experienced a slight increase in average curvature for all subjects. The time constant of lens thickness and lens curvature were similar.

Conclusions : This study demonstrates the feasibility of quantifying the dynamic changes in lens curvature and thickness during accommodation using extended-depth OCT combined with a step accommodation stimulus and an automated segmentation algorithm.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Accommodative responses for 22yo subject. Graphs show radius of anterior lens (left), posterior lens (center) and lens thickness at the center of the pupil over time (right).

Accommodative responses for 22yo subject. Graphs show radius of anterior lens (left), posterior lens (center) and lens thickness at the center of the pupil over time (right).

 

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