September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Age-Related Variations in Foveal Avascular Zone Geometry and Vessel Density - an Optical Coherence Tomography Angiography (OCTA) study
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Author Affiliations & Notes
  • Richard B Rosen
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Brian Krawitz
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Shelley Mo
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Lawrence Geyman
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Erika Phillips
    Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
  • Joseph Carroll
    Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
  • Rishard Weitz
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York, United States
  • Toco Yuen Ping Chui
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Richard Rosen, Allergan (C), Carl Zeiss Meditech (C), Clarity (C), NanoRetina (C), Ocata Therapeutics (ACT) (C), OD-OS (C), Opticology (I), Optovue (C), Regeneron (C); Brian Krawitz, None; Shelley Mo, None; Lawrence Geyman, None; Erika Phillips, None; Joseph Carroll, ImagineEyes (C), Optovue (C); Rishard Weitz, None; Toco Chui, None
  • Footnotes
    Support   Marrus Family Foundation, Bendheim-Lowenstein Family Foundation, Wise Family Foundation, New York Eye and Ear Chairman¹s Research Fund, NEI U01 EY025477-01, Violett Fund, Milbank Foundation, Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5501. doi:
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      Richard B Rosen, Brian Krawitz, Shelley Mo, Lawrence Geyman, Erika Phillips, Joseph Carroll, Rishard Weitz, Toco Yuen Ping Chui; Age-Related Variations in Foveal Avascular Zone Geometry and Vessel Density - an Optical Coherence Tomography Angiography (OCTA) study
      x. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5501.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : : To study the influence of age on foveal avascular zone (FAZ) geometry and vessel density in a healthy population using OCTA.

Methods : OCTA perfusion maps 3x3 mm were obtained in 50 subjects (50 eyes) aged between 5 and 74 (mean±SD: 38±19 years) using a commercial system (AngioVue, Avanti RTVue-XR, Optovue). For each eye, a region of interest (ROI) defined as the area within 200μm of the FAZ margin was generated using distance transformation (Fig. A). Foveal vascular network was skeletonized in a semiautomatic fashion using custom MATLAB programs (Fig. B). Quantitative measurements of the FAZ including area, effective diameter, and acircularity index were obtained. Foveal vessel density was computed within the 200μm ROI (Fig. C), as well as quadrant-specific regions (superior, inferior, nasal, and temporal). Individual retinal magnification factor was corrected using axial length. Pearson’s correlation was used to analyze age vs OCTA parameters.

Results : Variability of FAZ among healthy subjects was considerable. Mean±SD values for FAZ area, effective FAZ diameter, and FAZ acircularity index were 0.20±0.07mm2, 498±99µm, and 1.39±0.14, respectively. Age did not significantly correlate with variation in any of the FAZ parameters. Mean±SD of foveal vessel density measured within 200µm ROI was 35.27±2.32mm-1. Vessel density was the highest inferiorly (36.16±3.04mm-1), followed by superior (35.55±3.00mm-1), temporal (34.74±2.64mm-1), and nasal (33.85±3.13mm-1) quadrants. No significant correlation was found between vessel densities and age.

Conclusions : FAZ geometry and vessel density as measured using OCTA, appear to be unaffected by age. These findings further substantiate prior studies performed with less advanced technologies.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Top row: a 25-year-old male. Bottom row: of a 56-year-old male. A&D) OCTA foveal perfusion map, B&E) superimposed OCTA perfusion map and skeletonized vasculature, C&F) colorized vessel density contour map.

Top row: a 25-year-old male. Bottom row: of a 56-year-old male. A&D) OCTA foveal perfusion map, B&E) superimposed OCTA perfusion map and skeletonized vasculature, C&F) colorized vessel density contour map.

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