September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Toward quantitative OCT angiography: visualizing flow impairment using variable interscan time analysis (VISTA)
Author Affiliations & Notes
  • Stefan B Ploner
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
  • Eric M Moult
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
    Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts, United States
  • Nadia K Waheed
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Lennart Husvogt
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
  • Julia Jennifer Schottenhamml
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
  • ByungKun Lee
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Joachim Hornegger
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
    School of Advanced Optical Technologies, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
  • Jay S Duker
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Philip J Rosenfeld
    Ophthalmology, Bascom Palmer Eye Institute - University of Miami Miller School of Medicine, Miami, Florida, United States
  • James G Fujimoto
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Stefan Ploner, None; Eric Moult, None; Nadia Waheed, Carl Zeiss Meditec Inc. (R), Iconic Therapeutics (C), Optovue Inc. (R), ThromboGenics (C); Lennart Husvogt, None; Julia Schottenhamml, None; ByungKun Lee, None; Joachim Hornegger, Optovue Inc. (F); Jay Duker, Carl Zeiss Meditec Inc. (F), Carl Zeiss Meditec Inc. (C), Optovue Inc. (F), Optovue Inc. (C); Philip Rosenfeld, Carl Zeiss Meditec Inc. (F); James Fujimoto, Carl Zeiss Meditec Inc. (P), Optovue Inc. (I), Optovue Inc. (P)
  • Footnotes
    Support  R01-EY011289-29A, R44-EY022864, R01-CA075289-16, FA9550-15-1-0473, FA9550-12-1-0499
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Stefan B Ploner, Eric M Moult, Nadia K Waheed, Lennart Husvogt, Julia Jennifer Schottenhamml, ByungKun Lee, Joachim Hornegger, Jay S Duker, Philip J Rosenfeld, James G Fujimoto; Toward quantitative OCT angiography: visualizing flow impairment using variable interscan time analysis (VISTA). Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCTA) is a promising modality for visualizing vascular alterations in a variety of ocular diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR). However, most OCTA techniques have limited dynamic range and do not provide information about the relative flow velocities within the imaged vasculature. Visualizing relative flow speed would be especially valuable when assessing diseases in which progression is linked to flow impairment, not just vasculature loss.

Methods : OCTA imaging of patients with various stages of AMD and DR was performed with a 1050 nm swept source OCT system at a 400 kHz A-scan rate using a 5 repeated B-scan protocol. Variable interscan time analysis (VISTA) was used to compute the OCTA decorrelation data from pairs of B-scans having 1.5 ms and 3.0 ms separations. The two resulting OCTA data sets were used to compute relative flow speeds, which were then mapped to a color space for display.

Results : The VISTA flow maps for a representative patient with non-proliferative DR (NPDR), and for a patient with geographic atrophy (GA) are shown in Figures 1 and 2, respectively. The VISTA map of the NPDR eye shows slower flows associated with capillary loops in the OCTA image. The VISTA map of the GA eye shows slower flows in the area of atrophy, and on the borders of atrophy.

Conclusions : A method for visualizing VISTA OCTA data is developed and used to differentiate flow speeds in DR and AMD eyes featuring GA. Differentiation of flow speeds is an important first step towards quantitative OCTA and may be useful for assessing vascular diseases at a reversible stage.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

OCTA and VISTA flow maps of NPDR (51 y/o female). (A) En face projection of the OCTA volume showing the retinal vasculature. (B) Corresponding VISTA flow map. (C) Enlargement of (A), showing a region of intercapillary loops. (D) Corresponding enlargement of the VISTA flow map, showing flow impairment within intercapillary loops. Scale bars: 1 mm.

OCTA and VISTA flow maps of NPDR (51 y/o female). (A) En face projection of the OCTA volume showing the retinal vasculature. (B) Corresponding VISTA flow map. (C) Enlargement of (A), showing a region of intercapillary loops. (D) Corresponding enlargement of the VISTA flow map, showing flow impairment within intercapillary loops. Scale bars: 1 mm.

 

OCTA and VISTA flow maps of non-exudative AMD with GA (77 y/o male). (A) En face projection of the OCTA volume through a ~35 um slab beginning at the choriocapillaris. (B) Corresponding VISTA flow map. (C) Enlargement of (A), showing selected choroidal vessels within the region of GA. (D) Corresponding enlargement of the VISTA flow map showing flow impairment in some vessels. Scale bars: 1 mm.

OCTA and VISTA flow maps of non-exudative AMD with GA (77 y/o male). (A) En face projection of the OCTA volume through a ~35 um slab beginning at the choriocapillaris. (B) Corresponding VISTA flow map. (C) Enlargement of (A), showing selected choroidal vessels within the region of GA. (D) Corresponding enlargement of the VISTA flow map showing flow impairment in some vessels. Scale bars: 1 mm.

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