September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Automated Identification of Retinal Nerve Fiber Bundle Connectivity in 9-field SD-OCT
Author Affiliations & Notes
  • Kyungmoo Lee
    Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
    Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, Iowa, United States
  • Hrvoje Bogunovic
    Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Young H Kwon
    Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, United States
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
  • Mona K Garvin
    Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
    Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, Iowa, United States
  • Andreas Wahle
    Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
    Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, Iowa, United States
  • Milan Sonka
    Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
    Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, Iowa, United States
  • Michael David Abramoff
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
    Iowa City VA Health Care System, Iowa City, Iowa, United States
  • Footnotes
    Commercial Relationships   Kyungmoo Lee, None; Hrvoje Bogunovic, None; Young Kwon, None; Mona Garvin, University of Iowa (P); Andreas Wahle, None; Milan Sonka, University of Iowa (P); Michael Abramoff, IDx LLC (I), IDx LLC (C), University of Iowa (P)
  • Footnotes
    Support  NIH Grants R01 EY019112, R01 EY018853, and R01 EB004640; the Department of Veterans Affairs; the Marlene S. and Leonard A. Hadley Glaucoma Research Fund; Clifford M. & Ruth M. Altermatt Professorship.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5941. doi:
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      Kyungmoo Lee, Hrvoje Bogunovic, Young H Kwon, Mona K Garvin, Andreas Wahle, Milan Sonka, Michael David Abramoff; Automated Identification of Retinal Nerve Fiber Bundle Connectivity in 9-field SD-OCT. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5941.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To propose an automated method that can identify patient-specific retinal nerve fiber bundle connectivity in a 9-field SD-OCT scan for analysis of glaucomatous damage along the entire retinal ganglion cell-axonal complex (RGC-AC).

Methods : 122×9 SD-OCT (Spectralis, Heidelberg Engineering, Inc., Germany) volumes to cover 60° on the retina were obtained from 122 eyes (67 OD, 55 OS) of 122 subjects (65.4±10.4 years, 39% male, 43, 39, 40 patients with early, moderate, advanced glaucoma, respectively). Each OCT volume consists of 768×61×496 voxels (9.53×8.07×1.92 mm3). After registering 9 OCT volumes to make a wide-field OCT volume, a retinal nerve fiber layer (RNFL) was automatically segmented using the graph-theoretic approach.1 The mean RNFL thickness for each grid sector was measured using a 24-2 Humphrey visual field (HVF) grid centered on the fovea (Fig. 1A). To detect retinal nerve fiber bundle connectivity, we used an A* graph search algorithm that is capable of finding an optimal path with the minimum aggregated cost from a starting node to one of the ending nodes. Sectors 10, 16, 17, 18, 25, 27, 34, 36, 42, 43, 44, 45 are ending nodes, and the other sectors are starting nodes. A graph was constructed by connecting each starting node (x, y) to node (x+1, y-1), node (x+1, y), and node (x+1, y+1) using arcs. The cost of each arc in the graph was calculated as follows: Cost (a, b) = (1–r2(a, b))●|RNFL(a, b)|, where r2(a, b) is the Pearson product moment correlation coefficient of the RNFL thickness between nodes a, b, and |RNFL(a, b)| is the RNFL thickness difference between nodes a, b.
1. Bogunovic H, Sonka M, Kwon YH, et al. Multi-surface and multi-field co-segmentation of 3-D retinal optical coherence tomography. IEEE Trans Med Imaging. 2014;33(12):2242-53.

Results : Figs. 1B-L show 11 typical examples with the retinal nerve fiber bundle paths of 9-field OCT volumes detected by our method, showing patient-specific nerve fiber bundle paths.

Conclusions : The proposed method was able to identify putative nerve fiber bundle paths in individual subjects with varying degrees of glaucoma severity from 9-field SD-OCT image analysis.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Figure 1. (A) 9-field OCT projection image overlaid with a 24-2 HVF grid. (B-L) 9-field OCT projection images overlaid with detected retinal nerve fiber bundle paths. The color of a line segment shows the number of overlapped paths.

Figure 1. (A) 9-field OCT projection image overlaid with a 24-2 HVF grid. (B-L) 9-field OCT projection images overlaid with detected retinal nerve fiber bundle paths. The color of a line segment shows the number of overlapped paths.

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