September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Corneal Peak Distance (PD) is Higher in Primary Angle Closure Glaucoma (PACG) Subjects than in Normal and Primary Open Angle Glaucoma (POAG) Subjects.
Author Affiliations & Notes
  • Owen Png
    Duke-NUS Graduate Medical School, Singapore, Singapore
  • Mani Baskaran
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Tin Tun
    Singapore Eye Research Institute, Singapore, Singapore
  • Sourabh Sharma
    Singapore Eye Research Institute, Singapore, Singapore
  • Yih Chung Tham
    Singapore Eye Research Institute, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Tin Aung
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Michael J A Girard
    National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Owen Png, None; Mani Baskaran, None; Tin Tun, None; Sourabh Sharma, None; Yih Chung Tham, None; Ching-Yu Cheng, None; Tin Aung, None; Michael Girard, None
  • Footnotes
    Support  NUSYIA_FY13_P03/R-397-000-174-133, NMRC/CSA/033/2012
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3549. doi:
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      Owen Png, Mani Baskaran, Tin Tun, Sourabh Sharma, Yih Chung Tham, Ching-Yu Cheng, Tin Aung, Michael J A Girard; Corneal Peak Distance (PD) is Higher in Primary Angle Closure Glaucoma (PACG) Subjects than in Normal and Primary Open Angle Glaucoma (POAG) Subjects.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3549.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate if corneal biomechanical parameters, measured by the Corvis (CST, Oculus Optikgeräte GmbH, Wetzlar, Germany), including the widely reported deformation amplitude, are significantly different amongst normal, PACG, and POAG subjects.

Methods : 194 Chinese subjects, comprising of 80 normal, 63 POAG and 51 PACG subjects, were recruited in this cross-sectional study. Patients with previous ocular surgeries or trauma were excluded. All recruited participants underwent a comprehensive ophthalmic examination, including visual acuity assessment, IOP measurement with Goldmann applanation tonometry, and automated refraction and keratometry. Corneal biomechanical parameters, including applanation length, time and velocity, deformation amplitude, peak distance and radius, were analyzed using the Oculus Corvis ST air-puff tonometer. Mean differences of the parameters amongst the subgroups were evaluated by statistical analysis of variance and multiple regression analyses. Sensitivity analysis was performed for regression after matching for age.

Results : The mean age and proportion of males were higher in the glaucoma subgroups. Corneal Peak distance (PD) deformation was lower in normal compared to glaucoma subjects [Normal:3.44 ± SD1.24mm vs POAG:4.30±1.22mm vs PACG:4.13 ±1.16mm, p<0.0001]. PD remained higher in only PACG subjects compared to normals after correcting for age, gender, spherical equivalent (SE), intraocular pressure (IOP) and central corneal thickness (OR 1.7, 95% CI 1.2,2.6, p=0.007). Deformation amplitude was not influenced by the type of glaucoma, but varied with IOP, age, gender and SE.

Conclusions : Corneal peak distance, but not deformation amplitude, was higher in PACG. Our results may reflect altered corneal biomechanical properties due to collagen remodeling in PACG eyes. Further investigations are required to assess the clinical relevance of biomechanical parameters as a predictor of glaucoma progression.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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