September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Total Retinal Blood Flow Measurements with En Face Doppler Optical Coherence Tomography in Eyes with Central Retinal Vein Occlusion
Author Affiliations & Notes
  • Mark Lane
    Ophthalmology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
    Tufts Medical Center, New England Eye Center, Boston, United Kingdom
  • ByungKun Lee
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Nadia K Waheed
    Tufts Medical Center, New England Eye Center, Boston, United Kingdom
  • Talisa E de Carlo
    Tufts Medical Center, New England Eye Center, Boston, United Kingdom
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Mehreen Adhi
    Tufts Medical Center, New England Eye Center, Boston, United Kingdom
  • WooJhon Choi
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Eric M Moult
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Jay S Duker
    Tufts Medical Center, New England Eye Center, Boston, United Kingdom
  • James G Fujimoto
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Mark Lane, None; ByungKun Lee, None; Nadia Waheed, Carl Zeiss Meditec: Research Support (F), Iconic therapeutics (C), OptoVue: Speaker (S), Thrombogenics: Speaker (S); Talisa de Carlo, None; Mehreen Adhi, None; WooJhon Choi, None; Eric Moult, None; Jay Duker, Carl Zeiss Meditec Inc (C), Carl Zeiss Meditec Inc (F), Optovue (F), OptoVue (C), Topcon Medical Systems Inc (C); James Fujimoto, Optovue Inc. (I), Royalties from intellectual property owned by the Massachusetts Institute of Technology and licensed to Carl Zeiss Meditec Inc, Optovue (P)
  • Footnotes
    Support  National Institutes of Health: R01-EY011289-29A, R44-EY022864, R01-CA075289-16. Air Force Office of Scientific Research: FA9550-15-1-0473, FA9550-12-1-0499
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 462. doi:
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    • Get Citation

      Mark Lane, ByungKun Lee, Nadia K Waheed, Talisa E de Carlo, Mehreen Adhi, WooJhon Choi, Eric M Moult, Jay S Duker, James G Fujimoto; Total Retinal Blood Flow Measurements with En Face Doppler Optical Coherence Tomography in Eyes with Central Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2016;57(12):462.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : En face Doppler optical coherence tomography (OCT) enables fully automatic calculation of total retinal blood flow (TRBF) in the central retinal artery. The aim of this study was to validate this new technique in patients with central retinal vein occlusion (CRVO) and to investigate the role of TRBF in the pathophysiology of CRVO.

Methods : TRBF was measured in both eyes of six subjects (64.0±19.8yo, 5 females) that suffered from unilateral CRVO. TRBF was also measured in one randomly selected eye of nine age/sex matched normal control subjects (62.1±10.4yo, 7 females). TRBF was measured using a 1050-nm wavelength SS-OCT prototype operating at 400-kHz axial scan rate. Volumetric Doppler OCT image comprising 600×80 axial scans over a 1.5mm×2mm area at the optic disc was repeatedly acquired 24 times in 3.4 seconds of total scanning time. TRBF was calculated in each volume by automated analysis software and averaged over the cardiac cycle (Figure 1).

Results : Mean TRBF was 26.9±6.3μL/min in eyes with CRVO, 52.9± 18.3μL/min in the fellow eyes without vascular occlusion, and 43.5± 8.4μL/min in normal eyes. The TRBF was significantly lower in the eyes with CRVO compared to the normal fellow eye (P≤0.02, two-tailed Welch's t-test) and the age/sex matched control eyes (P≤0.001, two-tailed Welch's t-test). The mean TRBF was higher in the unaffected fellow eyes of the CRVO patients than in normal control eyes, however due to a large spread of TRBF in the fellow eyes, this was not statistically significant.

Conclusions : A statistically significant decrease in TRBF in eyes affected with CRVO was observed. Further work is required to ascertain if there is a significant increase in TRBF in the fellow eye of patients that suffer from CRVO compared to normal control subjects and to assess the use of this technology in screening patients that are at risk of CRVO, to allow early detection and targeted lifestyle modification.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Fig. 1. TRBF measurement in a patient with unilateral CRVO. (A, D) En face Doppler OCT scan area marked on color fundus photographs. (B, C, E, F) Flow velocity en face profiles at systole and diastole. (G) Pulsatile TRBF in the two eyes. Scale bars 500µm.

Fig. 1. TRBF measurement in a patient with unilateral CRVO. (A, D) En face Doppler OCT scan area marked on color fundus photographs. (B, C, E, F) Flow velocity en face profiles at systole and diastole. (G) Pulsatile TRBF in the two eyes. Scale bars 500µm.

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