September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Macular SD-OCT Outcome Measures in Glaucoma: Comparison of Local Structure-Function Relationships and Dynamic Range
Author Affiliations & Notes
  • Kouros Nouri-Mahdavi
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Arezoo Miraftabi
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
    Ophthalmology, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Navid Amini
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Sharon Henry
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Esteban Morales
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Fei Yu
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Abdolmonem Afifi
    Biostatistics, UCLA's Fielding School of Public Health, Los Angeles, California, United States
  • Anne L Coleman
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Joseph Caprioli
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Kouros Nouri-Mahdavi, Allergan (C), Heidelberg Engineering (R); Arezoo Miraftabi, None; Navid Amini, None; Sharon Henry, None; Esteban Morales, None; Fei Yu, None; Abdolmonem Afifi, None; Anne Coleman, None; Joseph Caprioli, Allergan (C), Heidelberg Engineering (R)
  • Footnotes
    Support  Mid-Career Clinician Scientist Grant from American Glaucoma Society, NIH K23 grant (1K23EY022659), and Departmental funds from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Kouros Nouri-Mahdavi, Arezoo Miraftabi, Navid Amini, Sharon Henry, Esteban Morales, Fei Yu, Abdolmonem Afifi, Anne L Coleman, Joseph Caprioli; Macular SD-OCT Outcome Measures in Glaucoma: Comparison of Local Structure-Function Relationships and Dynamic Range. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : There is scant evidence regarding comparative utility of various macular SD-OCT thickness parameters for detection of glaucoma progression. We have previously found the local variability for all macular parameters to be very low and uniform across the macula. The goal of this study is to compare the performance of inner macular thickness parameters with regard to local structure-function (SF) relationships and dynamic range of measurements.

Methods : One hundred fifteen glaucomatous eyes from 102 patients, including 17 eyes with intact achromatic visual field, and 16 normal eyes (8 subjects) with macular SD-OCT images (Spectralis) and 10-2 visual fields were enrolled. Macular images were segmented and inner plexiform layer (IPL), ganglion cell layer (GCL), and GC/IPL thicknesses were calculated for an 8x8 array of 3-degree superpixels. The main outcome measures used to compare macular parameters were: 1) local structure-function (SF) relationships within the central 18 degrees of the macula after adjusting for macular retinal ganglion cell displacement, and 2) dynamic range of measurements, defined as the difference between the median of the top highest 5% of measurements and the bottom plateau of OCT measurements (the intercept of Hood’s simple linear model) and the change point, i.e. the local total deviation value where the macular paramters reach the bottom plateau.

Results : The average visual field mean deviation was −6.8 (± 5.4) dB in the glaucoma group. The strength of SF relationships was similar among all thickness measures (rho = 0.571, 0.519, and 0.578 for GCL, IPL, and GC/IPL, respectively; p >0.05 for the difference). The highest SF correlations coincided with the peak of the GCL thickness (rho = 0.610, 0.618, and 0.637). The dynamic range was highest for the GC/IPL (57μ) followed by GCL (36μ), and IPL (22μ)(Figure). The change points were very similar among all the parameters as follows: IPL=−8.4 dB, GCL=−8.7 dB, and, GC/IPL=−8.6 dB.

Conclusions : The strength of structure-function relationships and the latter's point of change were similar for all inner macular parameters. Given the similar variability for the 3 macular parameters, the higher dynamic range, and the less demanding segmentation, GC/IPL provides the best compromise for detection of change over time with current SD-OCT technology.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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