September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Evaluation of a new, low-cost, portable, wide-field, digital, retinal camera, “Neo” for screening infants for Retinopathy of Prematurity – A prospective, multi-center, validation report in Asian Indian infants
Author Affiliations & Notes
  • Anand Vinekar
    Pediatric Retina, Narayana Nethralaya Eye Hospital, Bangalore, Kamataka, India
  • Mangat Ram Dogra
    Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Chaitra Jayadev
    Pediatric Retina, Narayana Nethralaya Eye Hospital, Bangalore, Kamataka, India
  • Seema Murthy
    Public Health, Head Held High Services, Bangalore, India
  • Shyam Vasudeva Rao
    Maastricht University Medical Center, Bangalore, India
  • Bhujang Shetty
    Ophthalmology, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Footnotes
    Commercial Relationships   Anand Vinekar, None; Mangat Ram Dogra, None; Chaitra Jayadev, None; Seema Murthy, None; Shyam Vasudeva Rao, Fours Health, India (P); Bhujang Shetty, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Anand Vinekar, Mangat Ram Dogra, Chaitra Jayadev, Seema Murthy, Shyam Vasudeva Rao, Bhujang Shetty; Evaluation of a new, low-cost, portable, wide-field, digital, retinal camera, “Neo” for screening infants for Retinopathy of Prematurity – A prospective, multi-center, validation report in Asian Indian infants. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate a new wide-field infant retinal camera, “Neo” (Forus Health, India), to screen for Retinopathy of Prematurity (ROP) and compare it with RetCam (Clarity MSI, USA) images of the same infant

Methods : 128 premature Asian Indian infants from 35 neonatal centers were screened using the RetCam and the “Neo” alternately with either device first. A minimum of seven images from each eye including the dilated anterior segment was obtained from each device. Images from the “Neo” were cropped to resemble those of the RetCam. Two ROP specialists masked to the origin of the randomly presented images were provided with birth weights (BW), gestational age (GA) and postmenstrual ages (PMA) at imaging. They reported the presence of retinal immaturity, maturity or on the stage of ROP and zone of involvement, for each eye, in each session and reached a ‘decision’ on whether to treat, follow-up or discharge the baby based on the findings in both eyes

Results : 144 sessions of 128 infants (73 male: 55 female) were analyzed. The means for BW was 1485 grams, GA was 31.1 and PMA was 40.2 weeks respectively. The ‘Neo’ had a sensitivity of 97.4% and 99.3% and a specificity of 81.1% and 75.6% for detecting any stage ROP, for the two observers respectively. The kappa for clinical decision and agreement were 0.60 and 79% and 0.90 and 95% for the two observers respectively. Interrater agreeability for staging was 0.8 and 73.4% agreement. Both observers correctly identified all (n=27) zone 3 diseases on the ‘Neo’ images

Conclusions : The “Neo” is capable of wide field imaging in preterm infants. It compares well with the RetCam in detecting ROP (Fig 1 & 2). Images from the Neo were useful in deciding follow-up and discharge of these babies because the ability to image the periphery. This novel, low-cost camera has a good screening potential especially in developing countries

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Figure 1. An infant born at 32 weeks of gestation with 1530 grams, imaged at 41+3 days showing a regressing stage 2 ROP in zone 2 anterior on the ‘Neo’ (above) and on the RetCam (below)

Figure 1. An infant born at 32 weeks of gestation with 1530 grams, imaged at 41+3 days showing a regressing stage 2 ROP in zone 2 anterior on the ‘Neo’ (above) and on the RetCam (below)

 

Figure 2: Immature retina imaged at 34 weeks postmenstrual age (PMA) on the ‘Neo’ (A) and on the RetCam (B).
Mature retina in another infant showing vessels up to the ora serrata at 42 weeks PMA on the ‘Neo’ (C) and RetCam (D) respectively.

Figure 2: Immature retina imaged at 34 weeks postmenstrual age (PMA) on the ‘Neo’ (A) and on the RetCam (B).
Mature retina in another infant showing vessels up to the ora serrata at 42 weeks PMA on the ‘Neo’ (C) and RetCam (D) respectively.

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