September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Adaptive optics fundus camera/Optical coherence tomography system for high resolution retinal imaging using a compact design
Author Affiliations & Notes
  • Matthias Salas
    Center for Medical Physics and Biomedical Engineering , Medical University of Vienna, Vienna, Austria
  • Xavier Levecq
    Imagine Eyes, Orsay, France
  • Barbara Lamory
    Imagine Eyes, Orsay, France
  • Sonja Gudrun Prager
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Julia Hafner
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Markus Ritter
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Wolfgang Drexler
    Center for Medical Physics and Biomedical Engineering , Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering , Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Matthias Salas, None; Xavier Levecq, Imagine Eyes (E); Barbara Lamory, Imagine Eyes (E); Sonja Prager, None; Julia Hafner, None; Markus Ritter, None; Ursula Schmidt-Erfurth, None; Wolfgang Drexler, Imagine Eyes (F); Michael Pircher, Imagine Eyes (F)
  • Footnotes
    Support  The European project FAMOS (project number FP7 ICT 317744), Macular Vision Research Foundation (MVRF, USA), "Comprehensive Choridal an Cellular Resolution Retinal OCT of Macular Degernations" (FA605A0401) - internationally peer-reviewed US grant.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 57. doi:
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    • Get Citation

      Matthias Salas, Xavier Levecq, Barbara Lamory, Sonja Gudrun Prager, Julia Hafner, Markus Ritter, Ursula Schmidt-Erfurth, Wolfgang Drexler, Michael Pircher; Adaptive optics fundus camera/Optical coherence tomography system for high resolution retinal imaging using a compact design. Invest. Ophthalmol. Vis. Sci. 2016;57(12):57.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To design, build and test a compact prototype imager that is suitable for clinical environment. To combine two different imaging modalities, adaptive optics fundus camera (AO-FC) and AO-optical coherence tomography (OCT) into a single instrument.

Methods : The AO-FC is based on a commercial product (RTX1, France). The AO-OCT is operated at 840nm with an A-scan rate of 200kHz, which is translated into a volume acquisition rate of 1.25 volumes per second (2ox2o FOV, 400x365pixels). Both imaging modalities share the same AO correction path. The relay optics of the AO system is entirely based on lenses, which allows a very compact design. AO runs in closed loop mode and is based on wavefront measurements using a Hartmann Shack wavefront sensor in combination with a laser beacon. Wavefront correction is done using a 52 element deformable mirror (Mirao 52e). The sample arm including the fundus camera, wavefront sensing and wavefront correcting part has an extension of 40cmx50cmx20cm and is mounted on a 3D translation stage which is operable by a joystick.

Results : The instrument has been tested in healthy volunteers, in patients with Stargardt disease (SD) and diabetic retinopathy (DR). In SD abnormal cone spacing and cone morphology was observed on the AO-FC images. In the AO-OCT data sets hyper-reflective flecks of lipofuscin were clearly resolved in depth. In DR the focus was set on the visualization of microaneurysms. AO-OCT allows a clear 3D observation and an accurate localization of these structures. The content of microaneurysms can be visualized without disturbing lensing effect. Finally, AO-OCT allows measuring the volumes of these microaneurysms which might be of importance for follow up studies.

Conclusions : The AO-fundus camera provides a fast preview with larger field of view which simplifies subject alignment and localization of the regions of interest. Complementary information is provided and a comparison with other state of the art imaging modalities is simplified. The instrument is easy to use and can be operated with a single person which fits well for a more widespread clinical use of the instrument.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

A) AO-fundus image (4ox4o) recorded from a healthy volunteer, B) Single B-scan acquired at the location indicated with a green line, C) Average of 30 B-scans from the volume scan, D) Extracted en-face image from the AO-OCT volume.

A) AO-fundus image (4ox4o) recorded from a healthy volunteer, B) Single B-scan acquired at the location indicated with a green line, C) Average of 30 B-scans from the volume scan, D) Extracted en-face image from the AO-OCT volume.

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