September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Photoreceptor visibility surrounding different types of subretinal drusenoid deposits (SDD) revealed by adaptive optics scanning laser ophthalmoscopy (AOSLO)
Author Affiliations & Notes
  • XIAOYU XU
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
  • Xing Liu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
  • Xiaolin Wang
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Yuhua Zhang
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Footnotes
    Commercial Relationships   XIAOYU XU, None; Xing Liu, None; Xiaolin Wang, None; Yuhua Zhang, None
  • Footnotes
    Support  NIH R01EY024378, P30 EY003039,and institutional support from Research to Prevent Blindness, EyeSight Foundation of Alabama, Buck Trust of Alabama, Science and Technology Planning Project of Guangdong Province, China, 2012B050600032, Science and Technology Program of Guangzhou, China, 2013J4500019, Fundamental Research Funds of the State Key Laboratory of Ophthalmology, China and International Program for Ph.D. Candidates, Sun Yat-Sen University, China.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1624. doi:
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    • Get Citation

      XIAOYU XU, Xing Liu, Xiaolin Wang, Yuhua Zhang; Photoreceptor visibility surrounding different types of subretinal drusenoid deposits (SDD) revealed by adaptive optics scanning laser ophthalmoscopy (AOSLO). Invest. Ophthalmol. Vis. Sci. 2016;57(12):1624.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the microstructure of photoreceptors surrounding dot and ribbon SDD [PMID: 24503406] using AOSLO.

Methods : A total of 28 eyes of 14 patients with diagnosed age-related macular degeneration (AMD) and SDD were enrolled. SDD subtypes were determined and differentiated using color fundus photograph, infrared reflectance, autofluorescence images, and spectral-domain optical coherence tomography (SD-OCT). SDD were classified using an OCT-based 3-stage grading system. SDD lesions and surrounding photoreceptors were examined using AOSLO. The observation was repeated 3 times over 3.5 years.

Results : Dot SDD were found in 22 eyes of 11 patients. Ribbon SDD were found in 2 eyes of 1 patient. Both forms were seen together in 4 eyes of 2 patients. For dot SDD at stage 3, AOSLO presented a typical pattern showing a central reflective core of the lesion material surrounded by a hyporeflective annulus. Photoreceptor mosaic was visible outside this SDD affected area. For ribbon SDD at the same stage, AOSLO revealed a similar lesion structure as that of the dot SDD. However, photoreceptors adjacent to the lesion were illegible.

Conclusions : The absence of photoreceptor mosaic in ribbon SDD may indicate degeneration in the photoreceptor outer segment and the interdigitation zone that impairs the waveguide property of the photoreceptors. Our study implied the possible differentiation of disease outcome and prognosis in different subtypes of SDD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Figure 1. Multimodal imaging of SDD. A-C are multimodal images of dot SDD. A. Discrete hypofluorescent spots in autofluorescence (AF) image of the macular. B. SD-OCT image taken through the green line in panel A. The ellipsoid zone (EZ) band was discernible in areas between SDD lesions. C. Typical en face appearance of SDD in AOSLO taken through the blue box in panel A. D-F are multimodal images of ribbon SDD. D. Interconnected hypofluorescent bands in AF image. E. SD-OCT image taken through the green line in panel D. The continuous accumulation of SDD material made the EZ band invisible. F. The AOSLO image taken through the blue box in panel D, no illegible photoreceptor mosaic adjacent to the SDD lesion was shown. Color arrowheads point to the corresponding SDD imaged in different imaging modalities.

Figure 1. Multimodal imaging of SDD. A-C are multimodal images of dot SDD. A. Discrete hypofluorescent spots in autofluorescence (AF) image of the macular. B. SD-OCT image taken through the green line in panel A. The ellipsoid zone (EZ) band was discernible in areas between SDD lesions. C. Typical en face appearance of SDD in AOSLO taken through the blue box in panel A. D-F are multimodal images of ribbon SDD. D. Interconnected hypofluorescent bands in AF image. E. SD-OCT image taken through the green line in panel D. The continuous accumulation of SDD material made the EZ band invisible. F. The AOSLO image taken through the blue box in panel D, no illegible photoreceptor mosaic adjacent to the SDD lesion was shown. Color arrowheads point to the corresponding SDD imaged in different imaging modalities.

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