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Cui Rui, Qi Zhao, Wenli Yang, Yongpeng Zhang, Bin Mo, Wenbin Wei; Structural changes by spectral domain optical coherence tomography in patients with Coats disease. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1656.
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© 2017 Association for Research in Vision and Ophthalmology.
To evaluate the morphological characteristics as well as the relationship of visual acuity and morphological changes with Coats disease by analyzing optical coherence tomography (OCT) .
Retrospective case series of 31 eyes of 31 patients (27males, mean age 9.09±4.65 years, range 3-18 years) who were clinical diagnosed of Coats disease were included in the study. All patients underwent examination of visual acuity and optical coherence tomography (Zeiss Cirrus 5000 HD-OCT). The relationship between macular lesions and visual acuity were analyzed by Logistic regression test and Prarson correlation analysis. The differences were considered significant at P<0.05.
The structural changes include exudation, macular edema, retinal detachment, preretinal proliferative membrane, retinoschisis, ellipsoidal region lesion, retinal pigment epithelium (RPE) lesion and vitreous opacity (Fig.1).Exudation are observed in all 31 eyes, exudative aggregation was formed in 26 (83.87%) cases. Exudation are distributed inner retinal neuroepithelial layer in 30 eyes (96.77%), under retinal neuroepithelial layer in 18 eyes (58.06%) and under RPE in 14 eyes (12.90%), respectively. In 24 of these eyes (77.42%), OCT examination revealed retinal edema, including 7 extensive retinal edema and 17 cystoid macular edema. Moreover, 27 (87.10%) ellipsoidal region lesion, 24 (77.42%) RPE lesion, 23 (74.19%) preretinal proliferative membrane, 14 (45.16%) retinal detachment (fovea centralis are involved in 7 eyes), 13 (41.94%) vitreous opacity and 4 (12.90%) retinoschisis are observed. 7 vitreous organization occurred in all cases with vitreous opacities, six vitreous organization are closely connected with the surface of the retina.Statistical results show that only vitreous organization connected with retina was affecting factor of visual acuity damage (p=0.014) and it was a positively correlative factor(r=0.440, p=0.013).
The macular disease involved by Coats disease is complicated, but exudation, macular edema, preretinal proliferative membrane, ellipsoidal region lesion and RPE lesion are occurred in more than half of the patients. Vitreous organization connected with retina is an important affecting factor to visual acuity in Coats disease. OCT could help us to better analysis the condition of macular disease and expect visual impairment in some degree in Coats disease.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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