September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Novel fshape mapping of peripapillary RNFL and choroidal thickness for group-wise comparison of glaucoma and healthy aging
Author Affiliations & Notes
  • Sieun Lee
    Simon Fraser University, Vancouver, British Columbia, Canada
  • Karteek Popuri
    Simon Fraser University, Vancouver, British Columbia, Canada
  • Joanne A Matsubara
    University of British Columbia, Vancouver, British Columbia, Canada
  • Brennan Eadie
    University of British Columbia, Vancouver, British Columbia, Canada
  • Andrew Merkur
    University of British Columbia, Vancouver, British Columbia, Canada
  • Paul MacKenzie
    University of British Columbia, Vancouver, British Columbia, Canada
  • Marinko Venci Sarunic
    Simon Fraser University, Vancouver, British Columbia, Canada
  • Mirza Faisal Beg
    Simon Fraser University, Vancouver, British Columbia, Canada
  • Footnotes
    Commercial Relationships   Sieun Lee, None; Karteek Popuri, None; Joanne Matsubara, None; Brennan Eadie, None; Andrew Merkur, None; Paul MacKenzie, None; Marinko Sarunic, None; Mirza Faisal Beg, None
  • Footnotes
    Support  Brain Canada; Natural Sciences and Engineering Research Council of Canada (NSERC); Canadian Institutes of Health Research (CIHR); Michael Smith Foundation for Health Research (MSFHR); Alzheimer Society Canada; Pacific Alzheimer Research Foundation; Genome British Columbia
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3389. doi:
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      Sieun Lee, Karteek Popuri, Joanne A Matsubara, Brennan Eadie, Andrew Merkur, Paul MacKenzie, Marinko Venci Sarunic, Mirza Faisal Beg; Novel fshape mapping of peripapillary RNFL and choroidal thickness for group-wise comparison of glaucoma and healthy aging. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3389.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The functional shape (fshape) registration framework maps the retinal layer thickness measurements from multiple subjects into a common mean template space, allowing for a cross-sectional analysis in greater spatial detail than conventional point-wise or sectoral comparison. Using fshape mapping, we examined the group differences in the RNFL and choroidal thickness by age and presence of glaucoma.

Methods : 10 young healthy eyes (Group A, mean age: 29.8 ± 3.6), 10 older healthy eyes (Group B, mean age: 57 ± 4.4), and 18 older glaucomatous eyes (Group C, mean age: 61.7 ± 7.9) were imaged with a prototype swept-source OCT. The retinal nerve fiber layer (RNFL) and choroid were automatically segmented and their thickness was computed. Given a group of retinal surfaces, the fshape framework simultaneously estimates the mean template surface and mean thickness measurement mapping on the template. Using this framework, mean thickness maps were generated for each group, followed by point-wise Welch’s t-tests to identify the regions of significant difference due to healthy aging or glaucoma.

Results : Figure 1-a shows the group-mean RNFL thickness maps. All groups display the hourglass pattern with overall thinner RNFL in Group C. Figure 1-b shows group difference maps by age (left) and presence of glaucoma (right), with the latter displaying a pattern similar to the healthy RNFL thickness maps in Figure 1-a. Figure 1-c shows the p-values of the difference maps in Figure 1-b. The glaucoma-based difference (right) shows the highest significance in the inferior region.
Figure 2-a shows the group-mean choroidal thickness maps. In all groups, the choroid is thinner in the inferior region, and thicker in the nasal and superior regions. Group B shows the overall thinner choroid than Group A (Figure 2-b & c, left), with the nasal region showing the largest difference and statistical significance. Group C shows the thinner choroid than Group B (Figure 2-b & c, right), although the effect of glaucoma appears to be less than that of age. In both layers, the differences are the most pronounced where the layers are originally the thickest.

Conclusions : We performed group-wise comparison of the RNFL and choroidal layers in healthy aging and glaucoma using the novel fshape registration framework, showing detailed regional patterns not detectable by conventional point-wise or sectoral comparison.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

 

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