September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Fabrication and in-vitro characterization of novel hydrogel-based electrodes for visual prostheses
Author Affiliations & Notes
  • Yasuo Terasawa
    Vision Institute, R&D Div, NIDEK Co Ltd, Gamagori, Japan
    Materials Science, Nara Institute of Science and Technology, Ikoma, Japan
  • Hiroyuki Tashiro
    Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Yukari Nakano
    Vision Institute, R&D Div, NIDEK Co Ltd, Gamagori, Japan
  • Koji Osawa
    Vision Institute, R&D Div, NIDEK Co Ltd, Gamagori, Japan
  • Motoki Ozawa
    Nidek Co.,Ltd., Gamagori, Japan
  • Toshihiko Noda
    Materials Science, Nara Institute of Science and Technology, Ikoma, Japan
  • Takashi Tokuda
    Materials Science, Nara Institute of Science and Technology, Ikoma, Japan
  • Jun Ohta
    Materials Science, Nara Institute of Science and Technology, Ikoma, Japan
  • Kazutoshi Haraguchi
    College of Industrial Technology, Nihon University, Narashino, Japan
  • Footnotes
    Commercial Relationships   Yasuo Terasawa, Nidek Co.,Ltd. (E); Hiroyuki Tashiro, Nidek Co.,Ltd. (F); Yukari Nakano, Nidek Co.,Ltd. (E); Koji Osawa, Nidek Co.,Ltd. (E); Motoki Ozawa, Nidek Co.,Ltd. (E); Toshihiko Noda, Nidek Co.,Ltd. (F); Takashi Tokuda, Nidek Co.,Ltd. (F); Jun Ohta, Nidek Co.,Ltd. (F); Kazutoshi Haraguchi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3727. doi:
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      Yasuo Terasawa, Hiroyuki Tashiro, Yukari Nakano, Koji Osawa, Motoki Ozawa, Toshihiko Noda, Takashi Tokuda, Jun Ohta, Kazutoshi Haraguchi; Fabrication and in-vitro characterization of novel hydrogel-based electrodes for visual prostheses. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3727.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Charge injection capacity (CIC), the maximum injectable charge without causing irreversible electrochemical reactions, is important characteristic of stimulating electrode for visual prostheses. Introducing hydrogel onto electrode surface is expected to enhance in-vivo CIC, but fabrication of such electrode is difficult because of poor mechanical properties of hydrogel. The purpose of this study is to fabricate and characterize the novel hydrogel-based electrodes.

Methods : Electrode arrays were fabricated using polydimethylsiloxane (PDMS) and platinum foil. After forming 0.4mm-thick PDMS base layer, 0.02mm-thick platinum foil was stuck on the base layer. The platinum foil was then cut to form electrodes and conductive lines by femtosecond laser. Next, the electordes were coated with polyethylene glycol. After applying PDMS top layer, electrode surfaces were exposed by dissolving the polyethylene glycol with water. Nanocomposite hydrogel, composed of poly (N,N-dimethylacrylamide) and synthetic hectorite, was injected into the electrode openings to fill 0.5mm-diameter 0.4mm-height spaces above the platinum foil electrodes. CICs were measured in room-temperature PBS.

Results : Fabrication of hydrogel-coated electrodes was successfully performed by applying 90°C heat to the hydrogel in DI water after hydrogel injection into the electrode openings (see Fig.1).
The average CIC of non-hydrogel electrodes and hydrogel electrodes were 182µC/cm2 and 160µC/cm2 respectively. No statistically significant difference was observed between non-hydrogel electrodes and hydrogel electrodes (paired t-test, N=3).

Conclusions : The abovementioned results indicated that hydrogel had enough permeability of water and ions to pass the current of electrical stimulation. This suggested that the hydrogel-based electrode had a potential to enhance the in-vivo CIC because the application of hydrogel onto metal electrode intervened to deteriorate in-vivo CIC of conventional electrodes such as protein absorption and low counterion availability. We will study in-vivo performance of the hydrogel electrodes in the next step.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Fig.1 Electrode with hydrogel (right) and without hydrogel (left).

Fig.1 Electrode with hydrogel (right) and without hydrogel (left).

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