September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Bulbar conjunctival microcirculation and microvascular network in habitual contact lens wearers
Author Affiliations & Notes
  • Liang Hu
    Bascom Palmer Eye Insitute, Miami, Florida, United States
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Jin Zhou
    Bascom Palmer Eye Insitute, Miami, Florida, United States
    Guangzhou Women and Children’s Medical Center , Guangzhou, Guangdong, China
  • WAN CHEN
    Bascom Palmer Eye Insitute, Miami, Florida, United States
    Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China
  • Ye Yang
    Bascom Palmer Eye Insitute, Miami, Florida, United States
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Min Li
    Bascom Palmer Eye Insitute, Miami, Florida, United States
    Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China
  • Hong Jiang
    Bascom Palmer Eye Insitute, Miami, Florida, United States
  • Jianhua Wang
    Bascom Palmer Eye Insitute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Liang Hu, None; Jin Zhou, None; WAN CHEN, None; Ye Yang, None; Min Li, None; Hong Jiang, Johnson & Johnson Vision Product (F), University of Miami (P); Jianhua Wang, Johnson & Johnson Vision Product (F), University of Miami (P)
  • Footnotes
    Support  Supported by research grants in part from the UM SAC award, NANOS pilot study award, NIH Center Grant P30 EY014801, Research to Prevent Blindness (RPB), Department of Defense (DOD- Grant#W81XWH-09-1-0675).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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    • Get Citation

      Liang Hu, Jin Zhou, WAN CHEN, Ye Yang, Min Li, Hong Jiang, Jianhua Wang; Bulbar conjunctival microcirculation and microvascular network in habitual contact lens wearers. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study was to investigate the morphometry and hemodynamics of the bulbar conjunctival microvasculature between habitual contact lens wearers and non-contact lens wearers.

Methods : Custom built Functional Slit-lamp Biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva of contact lens wearers and non-contact lens wearers. All of the measurable venules were processed to yield vessel diameters and blood flow velocities. Fractal analysis using box counting (Dbox) and multifractal analysis (D0) representing microvascular network density and complexity was used to quantitatively analyze microvascular network. Ten habitual contact lens wearers (5 males, 5 females, age 25.7 ± 5.3 yrs) and 20 non-contact lens wearers (10 males, 10 females, age 29.6 ± 4.9 yrs) were enrolled. The average contact lens wearing history for habitual contact lens wearers was 9.1 ± 3.9 yrs (range: 3 to 16 years).

Results : The averaged blood flow velocity of habitual contact lens wearers was 0.81± 0.24 mm/s, which was significantly faster than non-contact lens wearers (0.47 ± 0.15 mm/s, P < 0.001). However, microvascular network density and complexity (Dbox = 1.63 ± 0.04, D0 = 1.62 ± 0.05) in contact lens wearers were not different compared to that (Dbox = 1.69 ± 0.03, D0 =1.68 ± 0.05) in non-contact lens wearers (both P > 0.05). There was no significant difference in vessel diameter between contact lens wearers(16.5 ± 2.3 µm) and non-contact lens wearers (17.3 ± 1.7 µm, P > 0.05).

Conclusions : Although there was no difference in microvascular network between two groups, increased blood flow velocity in habitual contact lens wearers indicates the vascular responses to contact lens, which may have a protective mechanism for successful lens wear.Future longitudinal studies with large sample sizes may validate the view point.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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