September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
OCT Angiography of Macular Ganglion Cell Complex Circulation in Glaucoma
Author Affiliations & Notes
  • Hana L Takusagawa
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • John C Morrison
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Yali Jia
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Liang Liu
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Beth Edmunds
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Lorinna Lombardi
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Rebecca Armour
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Ellen Davis
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • David Huang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Hana Takusagawa, None; John Morrison, None; Yali Jia, Optovue (F), Optovue (P); Liang Liu, None; Beth Edmunds, None; Lorinna Lombardi, None; Rebecca Armour, None; Ellen Davis, None; David Huang, Carl Zeiss Meditec (P), Optovue (F), Optovue (I), Optovue (P), Optovue (R)
  • Footnotes
    Support  R01 EY023285, DP3 DK104397, R01 EY024544, P30 EY010572, An unrestricted grant from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Hana L Takusagawa, John C Morrison, Yali Jia, Liang Liu, Beth Edmunds, Lorinna Lombardi, Rebecca Armour, Ellen Davis, David Huang; OCT Angiography of Macular Ganglion Cell Complex Circulation in Glaucoma. Invest. Ophthalmol. Vis. Sci. 201657(12):.

      Download citation file:


      © 2017 Association for Research in Vision and Ophthalmology.

      ×
  • Supplements
Abstract

Purpose : To detect macular circulation defects in glaucoma using optical coherence tomography (OCT) angiography.

Methods : One eye of each participant was imaged using a 70 kHz 840 nm wavelength spectral OCT system (RTVue-XR, Optovue, Inc) to obtatin a 6x6 mm volumetric angiography scan of the macula. The split-spectrum amplitude decorrelation angiography (SSADA) algorithm was used. A novel algorithm was used to remove flow projection artifact. The retina was segmented into two slabs: ganglion cell complex (GCC) defined as the nerve fiber layer to inner plexiform layer, and inner nuclear layer+outer plexiform layer (INL+OPL). The total retinal circulation was analyzed using a thick slab that included GCC and INL+OPL. An en face angiogram of each slab was obtained by maximum flow (decorrelation value) projection. Vessel density (VD), the percentage area occupied by vessels, was calculated from a 6x6 mm square region, excluding the foveal avascular zone.

Results : The study included 30 glaucoma and 30 age-matched normal participants. In normal eyes, a dense microvascular network in the macula was visible on en face OCT angiograms (Fig. 1A) which was attenuated in glaucomatous eyes (Fig. 1D). In normal participants, the intra-visit repeatability/population variability of GCC VD, INL+OPL VD, and total retinal VD were 1.8%/4.8%, 5.6%/13.7% and 1.3%/2.9% coefficient of variation, respectively. GCC VD in the glaucoma group (62.5% ± 8.7%; mean ± SD) was lower (P<0.001 Mann-Whitney U test) than the normal group (79.4% ± 3.8%). Total retinal VD in the glaucoma group (82.5% ±8.7%) was also significantly lower (P<0.001) than the normal group (91.0% ± 2.7%). INL+OPL VD in the glaucoma group (61.7% ± 10.5%) was not significantly lower (P=0.098) than the normal group (67.0% ± 9.2%). The area under the receiver operating curve for differentiating normal and glaucoma eyes was 0.984, 0.942 and 0.954 for GCC VD, total retinal VD, and GCC thickness, respectively. With specificity fixed at 95%, the sensitivity of GCC VD, total retinal VD and GCC thickness were 90%, 80% and 77%, respectively. GCC VD was highly correlated (r=0.892, P<0.001) with GCC thickness. GCC VD had a higher correlation with average retinal sensitivity over the corresponding VF points (r=0.453, P=0.012) than GCC thickness (r=0.399, P=0.029).

Conclusions : Glaucoma preferentially affects vessel density in the GCC. The GCC vessel density has high diagnostic accuracy in glaucoma.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×