September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Coffee (Caffeine) inhibits Cataract Formation in Humans
Author Affiliations & Notes
  • Shambhu D Varma
    Ophthalmology, Univ of Maryland Sch of Med, Baltimore, Maryland, United States
  • Krish Chandrasekaran
    Ophthalmology, Univ of Maryland Sch of Med, Baltimore, Maryland, United States
  • Footnotes
    Commercial Relationships   Shambhu Varma, None; Krish Chandrasekaran, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2499. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Shambhu D Varma, Krish Chandrasekaran; Coffee (Caffeine) inhibits Cataract Formation in Humans. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2499.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : We have previously shown that caffeine prevents cataractogenesis induced by high sugar levels as well as by UV. It does so by scavenging reactive oxygen species as well as by providing a metabolic support. The purpose of the present study was to examine the possibility of a correlation between caffeine intake and the prevalence of human cataract.

Methods : Prevalence of blindness due to various eye diseases published by WHO was used to obtain information on contribution of cataracts. Data on cataract blindness was then grouped in five zones according to its prevalence. Per capita coffee consumption was obtained from the FAO http://www.griequity.com/resources/BusinessGuides/DemographicsData/energy/energy-resource) and other agricultural sources. Caffeine derived from the coffee consumed was calculated from its percentage composition (~1%).

Results : The percentages of cataract blindness (Mean ±SD, N>6) were 55.25 ± 6.56, 51.68,± 6.51, 44.21±8.74, 26.28±4.39 and 5.21±0.75 in zones representing the African, American, Eastern Mediterranean , and Western and Eastern European regions. Caffeine consumption in the respective zones ranged from 0, 5.6±2.72, 34.28±21.94, 48.02±46.28, 213.83±61.58 (Mg/day). Thus there was an inverse correlation between the incidence of cataract blindness and caffeine intake, thus showing its statistically significant preventive effect; apparent also by regression analysis of the entire data (figure below).

Conclusions : The inverse correlation between the prevalence of cataract blindness and caffeine intake dependent on coffee drinking strongly suggests that this substance inhibits human cataract formation, in addition to its many other beneficial effects exerted against several neurological and cardiovascular complications, longevity and delaying the onset of diabetes. The results are in conformity with our previous studies showing its effectiveness in inhibiting cataract formation in the animal models.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Inverse correlation between cataract blindness (%) and caffeine intake. Spearman’s rank order correlation coefficient. -0.89; P< 0.001; R2 = ~0. 8

Inverse correlation between cataract blindness (%) and caffeine intake. Spearman’s rank order correlation coefficient. -0.89; P< 0.001; R2 = ~0. 8

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×