September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Retinal and choroidal features in active posterior uveitis and panuveitis assessed by swept-source optical coherence tomography
Author Affiliations & Notes
  • Alfredo Adan Civera
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Jessica Matas
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Angels De Pouplana
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Victor Llorenç
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Marina Mesquida
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Anna Sala
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Maria Teresa Sainz de la Maza
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Javier Zarranz-Ventura
    Ophthalmology, Hospital Clinic, Barcelona, Spain
  • Footnotes
    Commercial Relationships   Alfredo Adan Civera, None; Jessica Matas, None; Angels De Pouplana , None; Victor Llorenç, None; Marina Mesquida, None; Anna Sala, None; Maria Teresa Sainz de la Maza , None; Javier Zarranz-Ventura, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3411. doi:
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      Alfredo Adan Civera, Jessica Matas, Angels De Pouplana, Victor Llorenç, Marina Mesquida, Anna Sala, Maria Teresa Sainz de la Maza, Javier Zarranz-Ventura; Retinal and choroidal features in active posterior uveitis and panuveitis assessed by swept-source optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3411.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the retinal and choroidal changes observed in patients with uveitis assessed by swept source optical coherence tomography (SS-OCT, Atlantis DRI OCT-1, Topcon, Japan).

Methods : Single centre consecutive case series. SS-OCT images were qualitatively and quantitatively assessed after being manually corrected for segmentation errors. Qualitative analysis included: 1) presence of vitreomacular traction (VMT), 2) disruption of the ellipsoid line (EL), 3) presence and location of hyperreflective dots (HRD), 4) presence of subretinal and intraretinal fluid, 5) integrity of external limiting membrane (ELM), and 6) retinal pigment epithelium detachment with or without fluid, and 7) identification of the suprachoroidal space. Quantative analysis included a) retinal and b) choroidal thickness in the macula (early treatment of diabetic retinopathy study ETDRS grid total macular circle) and fovea (central subfield of the ETDSR grid).

Results : Twenty-five uveitis eyes (16 patients) were included in the study. 92% were non-infectious uveitis and 8% infectious, and according to the site of inflammation, uveitis was classified as posterior in 60.8% and panuveitis in 39.1% as per the Standardization of Uveitis Nomenclature criteria. VMT was observed in 16%, with disruption of the EL in 52% and presence of HRD in 24% of study eyes (83,3% in the outer retina and 16,6% in the inner retina). Subretinal and intraretinal fluid was detected in 28% and 40% of the study cohort, whereas ELM disruption was seen in 32% and RPE elevation in 36% (without subretinal fluid in 77,7% and with fluid in 22,2%) of study eyes. The suprachoroidal space was identified in only 12% of the cases. Mean retinal and choroidal thickness in the total macular circle was 301.6±44.8mm and 295.8±98.4mm, and in the fovea 273.1±89.6 and 296.9±118.8mm respectively.

Conclusions : SS-OCT allows adequate identification of retinal and choroidal features in posterior and panuveitis eyes. The longer wave-length of the laser source permits accurate delineation of deep retinal layers. However, the suprachoroidal space was observed only in a quarter of the study eyes. Future studies are required to elucidate the role of SS-OCT in the assessment of choroidal structures in uveitis.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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