September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Monitoring Intracranial Pressure By a Semi-automated Determination of Bruch's Membrane Deformation From Routine SD-OCT Volume Scans of the Optic Disc
Author Affiliations & Notes
  • Jason Agne
    Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa, United States
  • Jui-Kai Wang
    Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa, United States
  • Randy H Kardon
    Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, Iowa, United States
    The Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States
  • Mona K Garvin
    Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, Iowa, United States
    Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa, United States
  • Footnotes
    Commercial Relationships   Jason Agne, None; Jui-Kai Wang, None; Randy Kardon, Acorda (C), Department of Veterans Affairs Research Foundation, Iowa City, IA (S), Fight for Sight Inc (S), Novartis (C); Mona Garvin, The University of Iowa (P)
  • Footnotes
    Support  R01 EY023279
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4544. doi:
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      Jason Agne, Jui-Kai Wang, Randy H Kardon, Mona K Garvin; Monitoring Intracranial Pressure By a Semi-automated Determination of Bruch's Membrane Deformation From Routine SD-OCT Volume Scans of the Optic Disc. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4544.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In cases of optic disc swelling, it has been found that Bruch's membrane (BM) deformation towards the vitreous is associated with raised intracranial pressure (ICP). The degree of deformation also changes acutely with ICP severity, making it a candidate for monitoring short-term changes in ICP. Our group has previously used high density SD-OCT 5-line 2D raster scans of the optic nerve head (ONH) to quantify the deformation of BM using a statistical shape model. The use of 5-line raster scans offers the advantage of simplicity in identifying the centermost scan, where shape changes of BM are most pronounced. However, a 5-line raster scan of the ONH is not routinely obtained compared to the standard volume scan. In this work, we extract the 2D shape parameters from standard volumetric SD-OCT scans without requiring 5-line raster scans.

Methods : We generated an en face image using the 3D scan (Cirrus OCT 200x200 volume scan) and performed a segmentation of the ONH, to approximate BM opening (BMO). Using the center of BMO as a central scan, two manually determined landmarks were placed at the nasal and temporal edges. 18 more landmarks were automatically assigned to span a 2.5mm distance in each peripheral direction. The shape parameter of these landmarks was computed as it was done in our previous work (Fig. 1). A comparison of the shape parameter computed from the volume scan was made to those obtained from the 5-line raster scans in 22 patients with papilledema.

Results : The shape parameter describing BM deformation derived from the OCT scans showed a high correlation between the 3D volume scans and high density 5-line raster scans (Pearson's correlation coefficient = R2=0.967). The correlation plot is shown in Figure 2.

Conclusions : The shape parameter describing BM deformation can be obtained from routine 3D SD-OCT images. The significance is that changes in ICP reflected in deformation of BM can be monitored and quantified. This will provide a non-invasive approach for monitoring ICP and its effect at the ONH as well as response to medical and surgical treatments.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

The central slice found and the 20 landmarks for a BM curving away from the vitreous with a shape parameter of 3.82 (upper image) and towards the vitreous with a shape parameter of -4.46 (lower image).

The central slice found and the 20 landmarks for a BM curving away from the vitreous with a shape parameter of 3.82 (upper image) and towards the vitreous with a shape parameter of -4.46 (lower image).

 

The shape parameters of our method against the method using a 5-line raster scan.

The shape parameters of our method against the method using a 5-line raster scan.

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