September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Correlation between guttata density and Descemet’s membrane thickness in eyes with Fuchs’ endothelial corneal dystrophy
Author Affiliations & Notes
  • Jianyan Huang
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
  • Tudor Tepelus
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
  • Ping Huang
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
  • Cristina Modak
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
  • Srinivas R Sadda
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
    Doheny Eye Institute, Department of Ophthalmology, David Geffen School of MedicineDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States
  • Olivia L Lee
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
    Doheny Eye Institute, Department of Ophthalmology, David Geffen School of MedicineDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Jianyan Huang, None; Tudor Tepelus, None; Ping Huang, None; Cristina Modak, None; Srinivas Sadda, Allergan (F), Allergan (C), Avalanche (C), Bayer (C), Carl Zeiss Meditee (F), Genetech (F), Genetech (C), Iconic (C), Novartis (C), Optos (F), Optos (C), Regeneron (C), Stell cell Inc (C), Throbogenics (C); Olivia Lee, Allergan (F), Allergan (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5719. doi:
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      Jianyan Huang, Tudor Tepelus, Ping Huang, Cristina Modak, Srinivas R Sadda, Olivia L Lee; Correlation between guttata density and Descemet’s membrane thickness in eyes with Fuchs’ endothelial corneal dystrophy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5719.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To characterize Fuchs’ endothelial corneal dystrophy (FECD) using specular microscopy (SM) and spectral domain optical coherence tomography (SD-OCT).

Methods : The central cornea of 21 eyes with FECD and 15 eyes of age-matched normal controls were examined with the Konan NSP-9900 specular microscope(Konan Medical, Inc., Hyogo, Japan) and Heidelberg Spectralis SD-OCT (Heidelberg Engineering Gmbh, Heidelberg, Germany). Three images of the central cornea were taken with each instrument. The density of endothelial guttata based on specular images was graded on a 0-4 scale (Figure. 1) by two trained graders from the Doheny Image Reading Center. The thickness of the Descemet’s membrane and endothelial complex was manually calculated via analysis of the SD-OCT images using ImageJ (National Institutes of Health, Bethesda, Maryland, USA). Correlation between the guttata density and the thickness of Descemet’s membrane & endothelium was analyzed by SPSS 13.0.

Results : The thickness of Descemet’s membrane and endothelial complex in controls and the eyes with FECD was 19.3±2.3 µm and 34.8±11.6 µm, respectively (P<0.001). There was a positive correlation between guttata density and the thickness of Descemet’s membrane and endothelium in eyes with FECD (r=0.606, P=0.004).

Conclusions : The thickness of Descemet’s membrane and endothelium is increased in eyes with FECD, with the higher density of guttata correlating with increasing thickness. Specular microscopy combined with SD-OCT could represent a good approach to assess severity of FECD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Figure 1. DIRC Guttata Grading Scale for Specular Microspcopy.

Figure 1. DIRC Guttata Grading Scale for Specular Microspcopy.

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