September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Ricardo Noguera Louzada
    Ophthalmology, Federal University of Goiás, CEROF / UFG, Goiânia, GO, Brazil
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Eduardo Amorim Novais
    Ophthalmology, Federal University of São Paulo / UNIFESP, São Paulo, SP, Brazil
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Mehreen Adhi
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Emily Cole
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Eric M Moult
    Faculty of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Lennart Husvogt
    Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen-Nürnberg, Bavaria, Germany
    Faculty of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Andre J Witkin
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Caroline R Baumal
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • James G Fujimoto
    Faculty of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
  • Jay S Duker
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Nadia K Waheed
    Ophthalmology, New England Eye Center - Tufts University School of Medicine, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Ricardo Louzada, None; Eduardo Novais, None; Mehreen Adhi, None; Emily Cole, None; Eric Moult, None; Lennart Husvogt, None; Andre Witkin, None; Caroline Baumal, Allergan (S), Optovue (R); James Fujimoto, Optovue Inc (C), Royalties from intellectual property owned by the Massachusetts Institute of Technology and licensed to Carl Zeiss Meditec Inc., (C), Stock options Optovue Inc (C); Jay Duker, Alcon/Novartis (C), Allergan (C), Carl Zeiss Meditech (C), CoDa Therapeutics (C), Eleven Biotherapeutics (S), Lumenis (C), Omeros (C), Optovue (C), Thrombogenics (C); Nadia Waheed, Carl Zeiss Meditec (F), Iconic therapeutics (C), OptoVue (S), Thrombogenics (S)
  • Footnotes
    Support  This work was in part supported by a grant from the Macula Vision Research Foundation, New York, National Institute of Health (NIH R01-EY011289-28, R44-EY022864-03, R01-CA075289-17), Air Force Office of Scientific Research (AFOSR FA9550-10-1-0551 and FA9550-12-1-0499)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Ricardo Noguera Louzada, Eduardo Amorim Novais, Mehreen Adhi, Emily Cole, Eric M Moult, Lennart Husvogt, Andre J Witkin, Caroline R Baumal, James G Fujimoto, Jay S Duker, Nadia K Waheed; Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Cross-sectional, observational study to compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultra-high speed swept-source (SS)-optical coherence tomography angiography (OCTA) prototype versus a spectral-domain (SD)-OCTA device.

Methods : Patients were imaged on SD-OCT and SS-OCT devices on the same day. The SD-OCT device employed is the RTVue Avanti that operates at ~840nm wavelength and 70,000 A-scans/second. The SS-OCT device used is an ultra-high speed long-wavelength prototype that operates at ~1050nm wavelength and 400,000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the two devices using ImageJ. The non-parametric Wilcoxon signed-rank test was used to compare area measurements.

Results : Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type-1, 2 eyes (14.3%) as type-2, and 1 eye (7.1%) as mixed type. The mean CNV areas measured using SS-OCT and SD-OCT 3mm x 3mm OCTA were 0.949 ± 1.168mm2 and 0.340 ± 0.301mm2, respectively (p=0.001). For the 6mm x 6mm OCTA the CNV areas using SS-OCT and SD-OCT were 1.218 ± 1.284mm2 and 0.604 ± 0.597mm2, respectively (p=0.0019). The field of view did not significantly affect the measured CNV area (p=0.19 and p=0.18 for SS-OCT and SD-OCT respectively).

Conclusions : SS-OCTA measurements yielded significantly larger CNV areas than SD-OCTA. It is possible that SS-OCTA is better able to demarcate the full extent of CNV vasculature.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Multimodal imaging of a left eye with mixed type 1 and type 2 choroidal neovascularization. (A) Color fundus. Retinal pigment epithelium (RPE) clumps and mottling, and subretinal hemorrhage (white arrow) surrounded by hypocromic area and drusen.; (B) and (C) Fluorescein angiography at different stages. Red dashed-line representing the occult component; yellow dashed-line representing the classic component.; (D) Spectral-domain optical coherence tomography angiography (OCTA) image and; (E) Swept-source OCTA image. Red dashed-line representing the type 1 component; yellow dashed-line representing the type 2 component.; (F) Corresponding OCT B-scan. RPE represented as red dashed-line. Type 1 component (red arrow) and type 2 component (yellow arrow).

Multimodal imaging of a left eye with mixed type 1 and type 2 choroidal neovascularization. (A) Color fundus. Retinal pigment epithelium (RPE) clumps and mottling, and subretinal hemorrhage (white arrow) surrounded by hypocromic area and drusen.; (B) and (C) Fluorescein angiography at different stages. Red dashed-line representing the occult component; yellow dashed-line representing the classic component.; (D) Spectral-domain optical coherence tomography angiography (OCTA) image and; (E) Swept-source OCTA image. Red dashed-line representing the type 1 component; yellow dashed-line representing the type 2 component.; (F) Corresponding OCT B-scan. RPE represented as red dashed-line. Type 1 component (red arrow) and type 2 component (yellow arrow).

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