September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Dose and Time Response of Mn2+-enhanced Magnetic Resonance Imaging for Tracing Visual Pathway in vivo
Author Affiliations & Notes
  • Yuntao Hu
    Dept. of Ophthalmology, Beijing Tsinghua Changgung Hospital, Beijing, China
  • Weiling Wang
    Dept. of Ophthalmology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
  • Hui Xu
    Department of Radiology, Peking University Third Hospital, Beijing, China
  • Zhizhong Ma
    Dept. of Ophthalmology, Peking University Third Hospital, Beijing, China
  • Footnotes
    Commercial Relationships   Yuntao Hu, None; Weiling Wang, None; Hui Xu, None; Zhizhong Ma, None
  • Footnotes
    Support  This study was supported by a grant from the National Basic Research Program of China (973 Grant 2011CB707506), Seed Fund from the Peking University Third Hospital (NO.YZZ08-9-13) and Linghu Fund from the Peking University Third Hospital (NO.64508-01).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1674. doi:
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    • Get Citation

      Yuntao Hu, Weiling Wang, Hui Xu, Zhizhong Ma; Dose and Time Response of Mn2+-enhanced Magnetic Resonance Imaging for Tracing Visual Pathway in vivo. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1674.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To explore time and dose response of Mn2+-enhanced MRI for tracing visual pathway in vivo using intravitreal MnCl2 injection.

Methods : 36 rabbits were randomly divided into six groups (each group, n=6). 25μl MnCl2 in various concentrations (2, 5, 10, 15, 20, 40 mmol/L) was injected into vitreous of left eyes for each group respectively. MRI was performed to examine the imaging of visual pathway at 4, 6, 8, 12, 24 hours, and 2, 4, 7 days after intravitreal MnCl2 injection. The signal-noise ratio (SNR) of MRI in visual pathway was calculated and compared among different groups and time points.

Results : 2 mmol/L of MnCl2 just could induce optical nerve enhancement, but no image of lateral geniculate body and superior colliculus enhanced was found. In 5 - 40 mmol/L groups, the visual pathway from retina to contralateral superior colliculus were enhanced significantly [Fig.1]. However, no signal was enhanced in visual cortex in each group. The images were enhanced strongest at 24 h, and then the signals attenuated gradually from 24 h to 7 days.

Conclusions : Manganese-enhanced MRI for tracing visual pathway is related with time and dose of intravitreal Mn2+ injection.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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