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Amy Patel; OCT Angiography for Diagnosis and Possible Guided Laser Therapy of Choroidal Neovascular Membranes. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2137.
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© ARVO (1962-2015); The Authors (2016-present)
Choroidal neovascular membranes (CNVM) are associated with macular edema or subretinal fluid on traditional optical computed tomography (OCT), and vasculature dye leakage on indocyanine green (ICG) angiography. We hypothesize that OCT angiography (OCTA) can be an alternative, novel imaging technique that is also effective for diagnosing CNVM. Our aim is to describe and validate OCTA imaging for identifying CNVM and to superimpose OCTA on live fundus imaging as a potential platform for pre-programmed, targeted retinal laser treatment.
This is a case series in which ICG angiography, traditional OCT, and OCTA (AngioVue System by Optovue) imaging was performed on two patients with CNVM. Imaging was done prior to anti-VEGF treatment and 4 weeks after treatment. The feasibility of superimposing AngioVue images on live fundus imaging in a retina navigation laser treatment system (Navilas) was also evaluated.
Non-invasive OCTA consistently identified choroidal anomalies even with no evidence of subretinal fluid or macular edema on traditional OCT, or leakage on ICG. Choroidal anomalies were typically subfoveal or juxtafoveal. Anomalies were common sites of CNVM based on common finding on ICG or subretinal fluid recurrences. Furthermore, these OCTA images could be superimposed to live fundus imaging.
OCTA can reliably diagnose CNVM and be hybridized to a preprogrammed retinal laser treatment system. This may act as a platform for potential novel, targeted microsecond laser treatment of CNVM in the future.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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