September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Quantitative Multifunctional OCT imaging of nonpathologic optic nerve head
Author Affiliations & Notes
  • Young-Joo Hong
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan
  • Aaron C Chan
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan
  • Deepa Kasaragod
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan
  • Satoshi Sugiyama
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Tomey Corporation, Nagoya, Aichi, Japan
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan
  • Yasushi Ikuno
    Ikuno Eye Center, Osaka, Osaka, Japan
    Department of Ophthalmology, Osaka University, Suita, Osaka, Japan
  • Masahiro Miura
    Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan
  • Footnotes
    Commercial Relationships   Young-Joo Hong, Canon (F), Nidek (F), Tomey Corp. (F), Topcon Corp. (F); Aaron Chan, Canon (F), Nidek (F), Tomey Corp. (F), Topcon Corp. (F); Deepa Kasaragod, Canon (F), Nidek (I), Tomey Corp. (F), Topcon Corp. (F); Satoshi Sugiyama, Tomey Corp. (E); Shuichi Makita, Canon (F), Nidek (F), Tomey Corp. (F), Tomey Corp. (P), Topcon Corp. (F); Yasushi Ikuno, Tomey Corp. (F); Masahiro Miura, ALCON (F), BAYER (F), NOVARTIS (F), NOVARTIS (R), SANTEN (F), SANTEN (R); Yoshiaki Yasuno, Canon (F), Nidek (F), Tomey Corp. (F), Tomey Corp. (P), Topcon Corp. (F)
  • Footnotes
    Support  JSPS KAKENHI WAKATE B 15K20887
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 463. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Young-Joo Hong, Aaron C Chan, Deepa Kasaragod, Satoshi Sugiyama, Shuichi Makita, Yasushi Ikuno, Masahiro Miura, Yoshiaki Yasuno; Quantitative Multifunctional OCT imaging of nonpathologic optic nerve head. Invest. Ophthalmol. Vis. Sci. 2016;57(12):463.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : In order to investigate the tissue property of optic nerve head (ONH), quantitative optical coherence tomography (OCT) imaging was performed with 1-μm Jones-matrix multifunctional OCT (JM-OCT). This study aims at evaluating clinical utility of quantitative JM-OCT imaging, based on a descriptive normal ONH cases.

Methods : Five eyes of non-pathologic cases were imaged with quantitative JM-OCT. 3 mm × 3 mm areas around ONH were scanned with 512 × 1024 A-lines in 6.6 seconds. Intensity OCT, OCT signal attenuation coefficient (AC), complex correlation based OCT-angiography (OCA), local birefringence (LB) tomography, and degree-of-polarization-uniformity (DOPU) tomography were obtained from a volumetric scan. Each tomography represents the structure, combined coefficient of tissue scattering and absorption, vasculature, micro-structural property of tissue, and melanin, respectively. Contrast and properties of tissues in ONH are descriptively discussed.

Results : Fig. 1 shows an example of ONH with JM-OCT from high myopia. OCT projection (b) shows myopic conus. The conventional OCT intensity (a) shows moderate different intensity between prelamina (PL) and lamina cribrosa (LC) region. In contrast, the AC and LB images showed better discrimination of PL and LC. The log-scaled AC (d), LB (e), and correlation map (f) images shows high signal in LC relative to PL. The AC and LB images are less affected by upper tissue as shown in dashed loops region in (d,e). The DOPU (g) images show low value at the posterior of LC and peripapillary choroidal and scleral regions. Fig.1(h–m) show the en face slices of the AC (h, k), LB (i, l), and OCA (j, m) signals at the PL (h–j), and LC (k–m) regions. The difference between PL and LC is more clearly shown in the en face slice image as indicated with ellipses in (h–m). These observation was seen from all of five eyes.
The OCA projection (c) shows a portion of Zinn-Haller arterial circle (ZHAC, indicated with arrowhead) in the myopic conus. The ZHAC portion observed from two high myopic eyes (diopter: -8.50, -10.25).

Conclusions : The quantitative JM-OCT imaging gave clear discrimination of PL and LC with quantified values corresponding each tissue properties. The quantitative JM-OCT would enable quantitative assessment of in vivo ONH.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×