September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
The frequency of hemorrhages and microaneurysms in diabetic retinopathy is higher in the upper than the lower hemiretina
Author Affiliations & Notes
  • Giovanni Ometto
    Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark
  • Mogens Erlandsen
    Section for Biostatistics, Department of Public Health , University of Aarhus, Aarhus, Denmark
  • Andrew Hunter
    School of Computer Science, University of Lincoln, Lincoln, United Kingdom
  • Toke Bek
    Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark
  • Footnotes
    Commercial Relationships   Giovanni Ometto, None; Mogens Erlandsen, None; Andrew Hunter, None; Toke Bek, None
  • Footnotes
    Support  This research was made possible by a Marie Curie grant from the European Commission in the framework of the REVAMMAD ITN (Initial Training Research network), Project number 316990.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6338. doi:
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      Giovanni Ometto, Mogens Erlandsen, Andrew Hunter, Toke Bek; The frequency of hemorrhages and microaneurysms in diabetic retinopathy is higher in the upper than the lower hemiretina. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6338.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The presence and number of hemorrhages and microaneurysms (HE/MA) in diabetic retinopathy (DR) is an indication of the severity of the disease. It is known that the distribution of HE/MA shows regional differences, but it is unknown whether differences exist between the upper and the lower hemiretina.

Methods : Therefore, the location of all HE/MA was identified in digital fundus photographs of both eyes from 53 patients with moderate non-proliferative diabetic retinopathy, followed by manual confirmation of the identifications by an experienced grader. The retina was divided into the upper and the lower hemiretina by a horizontal line through the centre of the fovea and the optic disk. The number of lesions located above and below this line was compared using a binomial test.

Results : A total of 17728 HE/MAs were identified. No significant difference was found in the number of lesions between right and the left eye (p>0.3), but the number of lesions was significantly higher in the upper (61.6%) than in the lower (38.4%) hemiretina (p<0.001, binominal test). (Figure)

Conclusions : HE/MAs are more frequent in the upper than in the lower hemiretina. The difference may be due to differences in hydrostatic pressure between the upper and the lower retina with derived effects on retinal perfusion and the development of retinal vascular lesions.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

The cumulated distribution of HE/MA, ranging from dark red corresponding to the maximal occurrence of lesions to blue corresponding to no occurrence. Right eye to the top and left eye to the bottom.

The cumulated distribution of HE/MA, ranging from dark red corresponding to the maximal occurrence of lesions to blue corresponding to no occurrence. Right eye to the top and left eye to the bottom.

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