September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Quantitative evaluation of optical properties of optic nerve head tissues by multi-contrast optical coherence tomography
Author Affiliations & Notes
  • Aaron C Chan
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Young-Joo Hong
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Satoshi Sugiyama
    Tomey Corporation, Nagoya, Aichi, Japan
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Deepa Kasaragod
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Yasushi Ikuno
    Ikuno Eye Center, Osaka, Osaka, Japan
    Department of Ophthalmology, Osaka University, Suita, Osaka, Japan
  • Masahiro Miura
    Department of Ophthalmology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Footnotes
    Commercial Relationships   Aaron Chan, Canon (F), Nidek (F), Tomey Corporation (F), Topcon Corporation (F); Young-Joo Hong, Canon (F), Nidek (F), Tomey Corporation (F), Topcon Corporation (F); Satoshi Sugiyama, Tomey Corporation (E); Shuichi Makita, Canon (F), Nidek (F), Tomey Corporation (F), Tomey Corporation (P), Topcon Corporation (F); Deepa Kasaragod, Canon (F), Nidek (F), Tomey Corporation (F), Topcon Corporation (F); Yasushi Ikuno, Tomey Corporation (F); Masahiro Miura, Alcon (F), Bayer (F), Novartis (F), Novartis (R), Santen (F), Santen (R); Yoshiaki Yasuno, Canon (F), Nidek (F), Tomey Corporation (F), Tomey Corporation (P), Topcon Corporation (F)
  • Footnotes
    Support  Japan Society for the Promotion of Science KAKENHI 15K13371
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 828. doi:
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      Aaron C Chan, Young-Joo Hong, Satoshi Sugiyama, Shuichi Makita, Deepa Kasaragod, Yasushi Ikuno, Masahiro Miura, Yoshiaki Yasuno; Quantitative evaluation of optical properties of optic nerve head tissues by multi-contrast optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):828.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Quantitative evaluation of optical properties of tissues in the normal optic nerve head (ONH) are demonstrated by using multifunctional Jones-matrix optical coherence tomography (JM-OCT). The optical properties include degree of polarization uniformity (DOPU), local birefringence (LB), correlation-based OCT-angiography (OCA), scattering intensity (OCT intensity), and OCT-signal attenuation coefficient (AC). The statistical interrelationship among tissues and optical parameters are investigated. The interrelationship among the optical parameters, age and refractive error are also examined.

Methods : The left ONH of five healthy male subjects with ages ranging from 26 to 56 (mean ± SD, 36.8 ± 11.6) were scanned using 1.0-µm JM-OCT over a 3 mm x 3 mm transversal range at 100,000 A-scans/s. For each subject, tomograms of all of the optical parameters listed above were obtained. From horizontal B-scans of scattering intensity at the center of the ONH, the regions of the prelamina (PL), lamina cribrosa (LC), nasal and temporal peripapillary sclera (NPPS and TPPS) were manually delineated. Pearson’s correlations of the mean values among each region and each parameter are computed. Correlations of parameters with age and refractive error (in diopter) are also computed.

Results : Table 1 summarizes the correlations. The AC at PL has a strong negative correlation with the OCA at LC (r = -0.94, p = 0.016, row-a), which may indicate that high scattering in the PL is associated with low flow in the LC. The DOPU at LC has a significant, strong negative correlation with age (r = -0.90, p = 0.036, row-b). Possible causes include accumulation of deposit or melanin with age in the LC. Although it was insignificant (p = 0.055), strong correlation was found between birefringence at LC and refractive error (r = 0.87, row-e). The other significant correlations were summarized in Table 1. In addition, the AC image shows a significant improvement in LC-PL contrast than the OCT intensity image (Welch's two sample t-test, one-tailed, p = 0.0022).

Conclusions : The present analysis shows significant interrelationships among ONH tissues, its optical contrasts, age, and refractive error. These results suggest that quantitative JM-OCT can be useful for the investigation of the ONH. In comparison to scattering OCT, attenuation imaging would provide better quantitative assessment.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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