September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Detection of abnormal findings at the Bruch’s membrane to choriocapillaris level in central serous chorioretinopathy using en face OCT and indocyanine green angiography
Author Affiliations & Notes
  • Ari Shinojima
    Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
  • Kyoko Fujita
    Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
  • Ryusaburo Mori
    Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
  • Akiyuki Kawamura
    Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
  • Tsutomu Yasukawa
    Ophthalmology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Mitsuko Yuzawa
    Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Ari Shinojima, None; Kyoko Fujita, None; Ryusaburo Mori, None; Akiyuki Kawamura, None; Tsutomu Yasukawa, None; Mitsuko Yuzawa, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2158. doi:
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    • Get Citation

      Ari Shinojima, Kyoko Fujita, Ryusaburo Mori, Akiyuki Kawamura, Tsutomu Yasukawa, Mitsuko Yuzawa; Detection of abnormal findings at the Bruch’s membrane to choriocapillaris level in central serous chorioretinopathy using en face OCT and indocyanine green angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2158.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To clarify the Bruch’s membrane to choriocapillaris level abnormalities in central serous chorioretinopathy (CSC) eyes and unaffected contralateral eyes using en face OCT and indocyanine green angiography (ICGA).

Methods : The forty eyes of 20 CSC patients (18 men; 36 eyes, 2 women; 4 eyes) were examined. Data from 20 CSC eyes and 20 unaffected contralateral eyes were analyzed. The mean patient age was 47.8±11.2 years (range, 35-71 years). We performed fluorescein angiography and ICGA in all 20 patients to diagnose CSC. The Spectralis HRA+OCT (Heidelberg Retina Angiograph+OCT, Heidelberg Engineering) and TRC 50IX/Imagenet (Topcon, Tokyo, Japan) were also used. All patients underwent Swept source-OCT imaging (DRI OCT-1 “Atlantis”; Topcon Medical Inc.). Volume data for the posterior pole were acquired over a 12 by 9 mm area. The data were automatically segmented and flattened using prototype software (EnView; Topcon Medical Inc.), with Bruch’s membrane or the RPE serving as a reference plane for flattening. The modified volume data were analyzed to compare en face images and ICGA images at 30 minutes for each eye at varying pixel depths below the reference plane with a scale of 2.6 μm per pixel.

Results : All 20 CSC eyes (100%) and 12 of the 20 contralateral eyes (60%) showed abnormal findings on ICGA at 30 minutes. All 20 CSC eyes (100%) and 12 of the 20 contralateral eyes (60%) showed hyper-reflective portions on the en face OCT images at the Bruch’s membrane to choriocapillaris level. A partial correspondence was observed between the abnormal findings on 30-min ICGA and the hyper-reflective portion on en face images. However, in eight of the 20 contralateral eyes there were no abnormal findings at the Bruch’s membrane to choriocapillaris level on either ICGA or the en face images.

Conclusions : In CSC patients, abnormal fluorescence was detected in the late phase of ICGA, and these findings corresponded to abnormal lesions at the choriocapillaris to Bruch’s membrane level in en face images. Our findings suggest that one of the reasons for CSC development might be abnormalities at the Bruch’s membrane to choriocapillaris level.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Abnormal lesions were detected at the Bruch’s membrane to choriocapillaris level in en face image. Serous retinal detachment is seen in the B-scan.

Abnormal lesions were detected at the Bruch’s membrane to choriocapillaris level in en face image. Serous retinal detachment is seen in the B-scan.

 

ICGA findings at 30 minutes.

ICGA findings at 30 minutes.

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