September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Results from spectral-domain optical coherence tomography (SD-OCT) at baseline compared with normative data: The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Study
Author Affiliations & Notes
  • Alexander Ho
    Doheny Eye Institute, Los Angeles, California, United States
  • Beatriz E Munoz
    Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
  • Rupert Wolfgang Strauss
    Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
    Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Anamika Jha
    Doheny Eye Institute, Los Angeles, California, United States
  • Ngoc Lam
    Doheny Eye Institute, Los Angeles, California, United States
  • Zhihong Hu
    Doheny Image Analysis Laboratory, Doheny Eye Institute, Los Angeles, California, United States
  • David G Birch
    Retina Foundation of the Southwest, Dallas, Texas, United States
  • Eberhart Zrenner
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany
  • Sheila K West
    Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    David Geffen School of Medicine, UCLA, Los Angeles, California, United States
  • Hendrik P Scholl
    Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
  • Footnotes
    Commercial Relationships   Alexander Ho, None; Beatriz Munoz, None; Rupert Strauss, None; Anamika Jha, None; Ngoc Lam, None; Zhihong Hu, None; David Birch, None; Eberhart Zrenner, None; Sheila West, None; Srinivas Sadda, Carl Zeiss Meditec (F), Optos (F); Hendrik Scholl, None
  • Footnotes
    Support  Supported by the Foundation Fighting Blindness Clinical Research Institute (FFB CRI) and a grant to FFB CRI by the U.S. Department of Defense USAMRMC TATRC, Fort Meade, Maryland (grant numbers W81-XWH-07-1-0720 and W81XWH-09-2-0189).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2697. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alexander Ho, Beatriz E Munoz, Rupert Wolfgang Strauss, Anamika Jha, Ngoc Lam, Zhihong Hu, David G Birch, Eberhart Zrenner, Sheila K West, Srinivas R Sadda, Hendrik P Scholl; Results from spectral-domain optical coherence tomography (SD-OCT) at baseline compared with normative data: The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2697.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The multicenter observational ProgStar studies aim to characterize the natural history of Stargardt disease (STGD1). Retinal architecture metrics derived from SD-OCT in a subset of patients enrolled into the prospective ProgStar study at baseline visit are compared to those of normal subjects.

Methods : Baseline visit SD-OCT images for 113 genetically confirmed, randomly-selected STGD1 participants enrolled at 9 sites into ProgStar were evaluated at a central reading center (Doheny Image Reading Center/DIRC). SD-OCT images from both eyes were graded, when available. 20 eyes from 20 normal subjects were also evaluated. If thickness data were available for both eyes in the STGD1 data subset, one eye was randomly selected for inclusion in the analysis. Proprietary DIRC software was used to generate mean thicknesses in the central subfield and inner ring of the ETDRS-grid for the retinal pigment epithelium (RPE), photoreceptor outer segments (OS) and inner segments (IS), outer nuclear complex (ONC), and inner retina (InR) layers. ProgStar eye data were normalized using Z-scores.

Results : The mean age for ProgStar subjects was 33 years (SD=15). The mean age of the normal subjects was 29 years (SD=8). RPE, OS, IS, and ONC thickness measures collected from the STGD1 subset were outside 2 SDs of the normal eye data (Table 1).

Conclusions : Outer retinal layers (RPE, OS, IS, ONC) in the STGD1 data subset have statistically significantly less thickness as compared to normals. These differences are important for the design of interventional clinical trials in STGD1.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Table 1. Intraretinal layer metrics (average and SD of mean thickness) for normal eyes and ProgStar baseline visit eyes.

Table 1. Intraretinal layer metrics (average and SD of mean thickness) for normal eyes and ProgStar baseline visit eyes.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×