September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
A Cross-sectional Study Investigating Associations Between Reticular Macular Disease (RMD) and Coronary Artery Disease (CAD)
Author Affiliations & Notes
  • Patrick A Kaszubski
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Meleha Ahmad
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Andrew Hsu
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Aushim Kokroo
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Leyla Bayat
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Vivek Kumar
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Colleen Cunningham
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Theodore Smith
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Footnotes
    Commercial Relationships   Patrick Kaszubski, None; Meleha Ahmad, None; Andrew Hsu, None; Aushim Kokroo, None; Leyla Bayat, None; Vivek Kumar, None; Colleen Cunningham, None; Theodore Smith, None
  • Footnotes
    Support  This work was supported by an individual investigator research award from the Foundation Fighting Blindness (RTS), National Institutes of Health/National Eye Institute grant R01 EY015520 (RTS), and unrestricted funds from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Patrick A Kaszubski, Meleha Ahmad, Andrew Hsu, Aushim Kokroo, Leyla Bayat, Vivek Kumar, Colleen Cunningham, Theodore Smith; A Cross-sectional Study Investigating Associations Between Reticular Macular Disease (RMD) and Coronary Artery Disease (CAD). Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Reticular Macular Disease (RMD) is a phenotype of Age-Related Macular Degeneration (AMD), which features subretinal drusenoid deposits (SDD) and choroidal changes. It is an independent risk factor for both AMD progression and earlier death. The purpose of this study is to compare SDD prevalence and subfoveal choroidal thickness (SCTh) in subjects, aged 40-75, with Coronary Artery Disease (CAD) and healthy controls, to see if middle-aged subjects with CAD show early signs of RMD.

Methods : CAD was defined as history of myocardial infarction, positive stress test, or revascularization procedure. 70 CAD and 54 healthy control subjects completed a questionnaire regarding medical and ocular history, and underwent enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT). Images were evaluated for SCTh and SDD.

Results : Mean age was different between the two study groups; 62 for CAD vs. 55 for controls (P〈0.001). SDD prevalence was 30% (21/70) in CAD subjects, and 7% (4/54) in controls (P=0.003). SCTh was 208 ± 50µm in the CAD group, significantly thinner than the 234 ± 50µm found in controls (P=0.005). In multivariate analysis, SDD depended significantly on CAD status (P=0.03) but not age (P=0.06).

Conclusions : While previous studies have shown an overlap between AMD and CAD risk factors, the choroidal alterations seen in RMD could be the overt vascular substrate for this link. Our results suggest that early RMD, seen as an increased prevalence of SDD and thinner choroids, appears in the CAD group. Importantly, SDD prevalence is higher in the CAD group, even after controlling for the effect of age. These relationships may hold importance for understanding both the AMD and CAD disease processes, which could lead to improved care of both these populations.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Figure 1: IR and EDI-OCT of a CAD subject, demonstrating several SDD and a thin choroid.

Figure 1: IR and EDI-OCT of a CAD subject, demonstrating several SDD and a thin choroid.

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