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Yoshiaki Yasuno, Young-Joo Hong, Shuichi Makita, Deepa Kasaragod, Masahiro Miura; Local birefringence and polarization uniformity imaging of exudative macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):49.
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© ARVO (1962-2015); The Authors (2016-present)
Recently developed multi-contrast Jones-matrix optical coherence tomography (JM-OCT) has enabled multi-contrast three-dimensional (3-D) observation of posterior eye. A single scan of JM-OCT provides scattering OCT, birefringence tomography, degree-of-polarization-uniformity (DOPU) tomography, and OCT angiography (OCT-A). Among them, the birefringence tomography is new and its clinical utility is not yet well investigated. Here, we discuss the birefringence and DOPU properties of exudative macular degeneration.
Six eyes of polypoidal choroidal vasculopathy (PCV) and 8 eyes of age-related macular degeneration (AMD) were examined by a custom-made JM-OCT with a 1-μm probe. The transversal scanning area was 4.5 mm × 4.5 mm or 6 mm × 6 mm and a volumetric scanning time is 6.6s. A single scan provides the multiple tomographies listed above. The volumetric scattering OCT, birefringence, and DOPU were observed by an operator (YY). At first, retinal deposit, choroidal neovascularization (CNV) and hyper-scattering beneath retinal pigment epithelium (RPE) were identified in scattering OCT. The same location of the birefringence and DOPU tomographies were then observed.
Retinal deposit were found in all 6 eyes of PCV. For all eyes, the deposits were appeared with high birefringence and low DOPU (Fig. a-c, white arrows). Deposits were also found in 4 of 8 AMD eyes. Similar to PCV cases, all the 4 eyes showed high birefringence, but only 3 of 4 eyes showed low DOPU. CNV were found above RPE in 4 of 6 PCV eyes. All the 4 eyes showed moderate to high birefringence and high DOPU at the CNV (Fig. a-c, yellow arrows). CNV-above-RPE were found in 6 of 8 AMD eyes. Unlike PCV cases, the CNV showed low birefringence in 3 eyes and high to moderately high in 3 eyes. In contrast, the DOPU was high for 5 of the 6 eyes. An exceptional case with high birefringence and low DOPU is shown in Fig. d-f. Hyper scattering was found beneath RPE detachment in 4 of 6 PCV eyes. It was appeared with low birefringence and high DOPU in 3 of 4 eyes (Fig. g-i, arrows), it may be because this hyper scattering is abnormal vasculature.
Clinical features, such as CNV, in OCT can be further classified by JM-OCT. In addition, JM-OCT also provides OCT-A. And hence, JM-OCT can potentially be a comprehensive diagnostic tool of macular degenerations.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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