September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Local birefringence and polarization uniformity imaging of exudative macular degeneration
Author Affiliations & Notes
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Young-Joo Hong
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Deepa Kasaragod
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Masahiro Miura
    Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Footnotes
    Commercial Relationships   Yoshiaki Yasuno, Canon (F), Nidek (F), Tomey Corp. (F), Tomey Corp. (P), Topcon (F); Young-Joo Hong, Canon (F), Nidek (F), Tomey Corp. (F), Topcon (F); Shuichi Makita, Canon (F), Nidek (F), Tomey Corp. (F), Tomey Corp. (P), Topcon (F); Deepa Kasaragod, Canon (F), Nidek (F), Tomey Corp. (F), Topcon (F); Masahiro Miura, Alcon (F), Bayer (F), Novartis (F), Novartis (R), Santen (F), Santen (R)
  • Footnotes
    Support  Japan Society for the Promotion of Science KAKENHI 15K13371.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 49. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Yoshiaki Yasuno, Young-Joo Hong, Shuichi Makita, Deepa Kasaragod, Masahiro Miura; Local birefringence and polarization uniformity imaging of exudative macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):49.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Recently developed multi-contrast Jones-matrix optical coherence tomography (JM-OCT) has enabled multi-contrast three-dimensional (3-D) observation of posterior eye. A single scan of JM-OCT provides scattering OCT, birefringence tomography, degree-of-polarization-uniformity (DOPU) tomography, and OCT angiography (OCT-A). Among them, the birefringence tomography is new and its clinical utility is not yet well investigated. Here, we discuss the birefringence and DOPU properties of exudative macular degeneration.

Methods : Six eyes of polypoidal choroidal vasculopathy (PCV) and 8 eyes of age-related macular degeneration (AMD) were examined by a custom-made JM-OCT with a 1-μm probe. The transversal scanning area was 4.5 mm × 4.5 mm or 6 mm × 6 mm and a volumetric scanning time is 6.6s. A single scan provides the multiple tomographies listed above. The volumetric scattering OCT, birefringence, and DOPU were observed by an operator (YY). At first, retinal deposit, choroidal neovascularization (CNV) and hyper-scattering beneath retinal pigment epithelium (RPE) were identified in scattering OCT. The same location of the birefringence and DOPU tomographies were then observed.

Results : Retinal deposit were found in all 6 eyes of PCV. For all eyes, the deposits were appeared with high birefringence and low DOPU (Fig. a-c, white arrows). Deposits were also found in 4 of 8 AMD eyes. Similar to PCV cases, all the 4 eyes showed high birefringence, but only 3 of 4 eyes showed low DOPU. CNV were found above RPE in 4 of 6 PCV eyes. All the 4 eyes showed moderate to high birefringence and high DOPU at the CNV (Fig. a-c, yellow arrows). CNV-above-RPE were found in 6 of 8 AMD eyes. Unlike PCV cases, the CNV showed low birefringence in 3 eyes and high to moderately high in 3 eyes. In contrast, the DOPU was high for 5 of the 6 eyes. An exceptional case with high birefringence and low DOPU is shown in Fig. d-f. Hyper scattering was found beneath RPE detachment in 4 of 6 PCV eyes. It was appeared with low birefringence and high DOPU in 3 of 4 eyes (Fig. g-i, arrows), it may be because this hyper scattering is abnormal vasculature.

Conclusions : Clinical features, such as CNV, in OCT can be further classified by JM-OCT. In addition, JM-OCT also provides OCT-A. And hence, JM-OCT can potentially be a comprehensive diagnostic tool of macular degenerations.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×