September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
A Quantitative Assessment of the Iridocorneal Angle in Asian Patients with Open-angle Glaucoma or Ocular Hypertension Using Schwalbe’s Line-based Angle Biometrics
Author Affiliations & Notes
  • Jeff Penzner
    Allergan plc, Irvine, California, United States
  • Quoc Ho
    University of Colorado, Aurora, Colorado, United States
  • Xinghuai Sun
    Eye & ENT Hospital of Fudan University, Shanghai, China
  • Junyi Chen
    Eye & ENT Hospital of Fudan University, Shanghai, China
  • Liang Xu
    Beijing Tongren Hospital, Beijing, China
  • Ya Xing Wang
    Beijing Tongren Hospital, Beijing, China
  • Xiaoming Chen
    West China Hospital, Chengdu, China
  • Ni Li
    West China Hospital, Chengdu, China
  • Michael R Robinson
    Allergan plc, Irvine, California, United States
  • Michelle Chen
    Allergan plc, Irvine, California, United States
  • Susan S Lee
    Allergan plc, Irvine, California, United States
  • Footnotes
    Commercial Relationships   Jeff Penzner, Allergan plc (E); Quoc Ho, None; Xinghuai Sun, None; Junyi Chen, None; Liang Xu, None; Ya Xing Wang, None; Xiaoming Chen, None; Ni Li, None; Michael Robinson, Allergan plc (E); Michelle Chen, Allergan plc (E); Susan Lee, Allergan plc (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5127. doi:
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      Jeff Penzner, Quoc Ho, Xinghuai Sun, Junyi Chen, Liang Xu, Ya Xing Wang, Xiaoming Chen, Ni Li, Michael R Robinson, Michelle Chen, Susan S Lee; A Quantitative Assessment of the Iridocorneal Angle in Asian Patients with Open-angle Glaucoma or Ocular Hypertension Using Schwalbe’s Line-based Angle Biometrics. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5127.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantitatively describe the iridocorneal angle biometrics in a cohort of Asian patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).

Methods : Anterior segment optical coherence tomography (AS-OCT) five-line raster scans (Zeiss Cirrus HD-OCT 4000) of the inferior angle were obtained under dark conditions and images from a total of 213 eyes of 129 patients were analyzed for iridocorneal angle biometrics. Images were graded for ability to visualize Schwalbe’s line (SL), the superior iris surface, and angle recess. ImageJ1 software (1.49v) was used to measure the angle opening distance at SL (SL-AOD) and trabecular-iris-space-area 500 μm posteriorly from SL (SL-TISA) in gradable images.

Results : The mean ± SD SL-AOD was 0.70 ± 0.32 mm (median 0.69, range 0.09 – 1.9), and the mean ± SD SL-TISA was 0.26 ± 0.13 mm2 (median 0.26, range 0.04 – 0.8). The 25th, 50th, 75th, and 95th percentile SL-AODs and SL-TISAs were 0.46, 0.69, 0.88, 1.28 mm, respectively, and 0.17, 0.26, 0.34, 0.49 mm2, respectively. The Pearson product-moment correlation coefficient for SL-AOD and SL-TISA was 0.98.

Conclusions : Comparable angle measurements that have been documented in normal Asian patients are considerably smaller than the cohort of Asian OAG and OHT patients in this study2. These findings suggest that further study may be required to understand the differences in the iridocorneal angle morphology in Asian OAG and OHT versus normal subjects.

References
1 Rasband, W.S., ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA, http://imagej.nih.gov/ij/, 1997-2015.
2 He Y. et al., Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles., Br J Ophthalmol. 2015 Aug ; 99(8): 1097-102.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Figure 1. Frequency distributions of [a] Schwalbe’s Line-based angle opening distance (SL-AOD) and [b] trabecular-iris-space-area (SL-TISA)

Figure 1. Frequency distributions of [a] Schwalbe’s Line-based angle opening distance (SL-AOD) and [b] trabecular-iris-space-area (SL-TISA)

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