September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Motion Signal Detected in Cystic Spaces on Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Monica Michelotti
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Miao Zhang
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Thomas S Hwang
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Steven T Bailey
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Christina J Flaxel
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Andreas Lauer
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Phoebe Lin
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • J. Peter Campbell
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • David J Wilson
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • David Huang
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Yali Jia
    Casey Eye Institute, Oregon Health And Science Univeristy, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Monica Michelotti, None; Miao Zhang, None; Thomas Hwang, None; Steven Bailey, None; Christina Flaxel, None; Andreas Lauer, Oxford Biomedica (C); Phoebe Lin, None; J. Peter Campbell, None; David Wilson, None; David Huang, Carl Zeis Meditec, Inc (P), Optovue, Inc (F), Optovue, Inc (P), Optovue, Inc (I); Yali Jia, Optovue, Inc (F), Optovue, Inc (P)
  • Footnotes
    Support  NIH grants DP3 DK104397, R01 EY02544, R01 EY023285, P30-EY010572, and an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5453. doi:
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    • Get Citation

      Monica Michelotti, Miao Zhang, Thomas S Hwang, Steven T Bailey, Christina J Flaxel, Andreas Lauer, Phoebe Lin, J. Peter Campbell, David J Wilson, David Huang, Yali Jia; Motion Signal Detected in Cystic Spaces on Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5453.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To detect decorrelation signal within cystic spaces on optical coherence tomography (OCT) angiography.

Methods : Macular scans of participants with diabetic macular edema (DME) and neovascular aged related macular diseases (AMD) were taken using a spectral OCT system (RTVue-XR). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was applied to detect flow. Semi-automated segmentation was used to identify the outer retina. The maximum flow projection in this slab was used for grading the decorrelation signal within cysts.

Results : 64 eyes of 37 patient with diabetic retinopathy and 57 eyes of 57 patients with neovascular AMD were analyzed. Of these, 5 eyes of 4 patients with diabetes had decorrelation signal within intraretinal cysts and no eyes with AMD. Patients with decorrelation signal had a mean central macular thickness of 341± 74.5 microns. Two patients had been treated with focal laser and anti-VEGF therapy. These cysts were sometimes associated with adjacent lipid and were most commonly in the parafoveal region. The decorrelation was noted in smaller cysts and not in large cystic spaces.

Conclusions : We present the first report of decorrelation signal within cysts. Previously all decorrelation signals had been attributed to flow within vessel or artifacts. The decorrelation signals within cysts likely originate from moving particles. These particles could be lipid or protein exudates, or cells. They tend to be present in smaller cysts in diabetic retinal edema, and not in fluids associated with choroidal neovascularization.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

(A) En face OCT angiogram with cystic motion (B) Quantification of cystic spaces with detected decorrelation (C) Cross sectional angiogram showing intravascular flow in purple and cystic motion in blue.

(A) En face OCT angiogram with cystic motion (B) Quantification of cystic spaces with detected decorrelation (C) Cross sectional angiogram showing intravascular flow in purple and cystic motion in blue.

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