September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Photopic Negative Response Obtained Using a Handheld Electroretinography (ERG) Device: Repeatability and Comparison with Optical Coherence Tomography in Glaucoma
Author Affiliations & Notes
  • Zhichao Wu
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
    Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
  • Xavier Hadoux
    Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
  • Marc Sarossy
    Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
  • Jonathan G Crowston
    Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Zhichao Wu, None; Xavier Hadoux, None; Marc Sarossy, None; Jonathan Crowston, None
  • Footnotes
    Support  The Menzies Foundation, the Miller Foundation and the Dorothy Adele Edols Charitable Trust. The Centre for Eye Research Australia receives support for operational infrastructure from the Victorian government.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Zhichao Wu, Xavier Hadoux, Marc Sarossy, Jonathan G Crowston; Photopic Negative Response Obtained Using a Handheld Electroretinography (ERG) Device: Repeatability and Comparison with Optical Coherence Tomography in Glaucoma. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the repeatability of the photopic negative response (PhNR) measured using a newly commercially available, handheld full-field ERG device that utilizes self-adhering skin electrodes, and compare its magnitude of standardized deficit with neuroretinal parameters on spectral-domain optical coherence tomography (SD-OCT) in eyes with established or suspected glaucoma.

Methods : Sixty-eight eyes from 40 participants with established or suspected glaucoma (considered the glaucoma group) and 47 eyes from 25 normal participants were examined. The PhNR was measured from a combined waveform derived from two measurements with 200 sweeps each, and expressed as a ratio of the B-wave (PhNR/B ratio); each measurement took approximately 60 seconds to obtain. Repeatability of this parameter was also calculated as a percentage of its effective dynamic range (EDR). Retinal nerve fiber layer (RNFL) thickness and Bruch’s membrane opening minimum rim width (BMO-MRW) measurements were obtained from SD-OCT scans. ERG and OCT parameters for the glaucoma group were converted into Z-scores to provide a standardized measure of deficit.

Results : Comparing the two measurements obtained in each eye, the coefficient of repeatability (CoR) of the PhNR/B ratio was 30 ± 4% and 20 ± 2% of the EDR for the normal and glaucoma group respectively (P < 0.001). There was a significant correlation between the Z-scores of the PhNR/B ratio with RNFL thickness (R = 0.595, P < 0.001) and BMO-MRW (R = 0.305, P < 0.001). The average Z-scores for eyes in the glaucoma group were -1.79 ± 0.19, -2.27 ± 0.17 and -3.61 ± 0.44 for the PhNR/B ratio, BMO-MRW and RNFL thickness respectively, being significantly different with all pairwise comparisons (P ≤ 0.020).

Conclusions : Neuroretinal parameters on SD-OCT were significantly correlated with the PhNR of the full-field ERG, but obtained a greater magnitude of measured deficit when examining eyes with established or suspected glaucoma at cross-section. However, the ability to obtain PhNR measurements with such ease using this novel handheld ERG system and with such degree of repeatability using the protocol in this study may provide a valuable tool for objectively measuring short-term or longitudinal changes in neuroretinal function in eyes with glaucoma.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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