September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Optic disc perfusion in eyes with primary open angle glaucoma and normal tension glaucoma using optical coherence tomography-based microangiography
Author Affiliations & Notes
  • Karine D Bojikian
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Chieh-Li Chen
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Joanne C Wen
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Qinqin Zhang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Chen Xin
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Divakar Gupta
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Raghu C Mudumbai
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Murray A Johnstone
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, Washington, United States
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Philip P Chen
    Ophthalmology, University of Washington, KIRKLAND, Washington, United States
  • Footnotes
    Commercial Relationships   Karine Bojikian, None; Chieh-Li Chen, None; Joanne Wen, None; Qinqin Zhang, None; Chen Xin, None; Divakar Gupta, None; Raghu Mudumbai, None; Murray Johnstone, Allergan (P), Cascade Ophthalmics (C), Healonics (C), Ivantis (C), Sensimed (C); Ruikang Wang, Carl Zeiss Meditec (F), Carl Zeiss Meditec (P); Philip Chen, None
  • Footnotes
    Support  Unrestricted departmental grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2957. doi:
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    • Get Citation

      Karine D Bojikian, Chieh-Li Chen, Joanne C Wen, Qinqin Zhang, Chen Xin, Divakar Gupta, Raghu C Mudumbai, Murray A Johnstone, Ruikang K Wang, Philip P Chen; Optic disc perfusion in eyes with primary open angle glaucoma and normal tension glaucoma using optical coherence tomography-based microangiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2957.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.

Methods : One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program (Figure 1).

Results : Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes, but no differences were observed between POAG and NTG eyes. Univariate analysis revealed significant correlation between optic disc perfusion, visual field (VF) mean deviation (MD), VF pattern standard deviation (PSD), and rim area in both POAG and NTG groups (p≤0.0288) (Figure 2).

Conclusions : Optic disc perfusion detected by OMAG showed similar reduction between POAG and NTG groups compared to normal controls. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

 

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