September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Assessment of the ophthalmic artery and the superior ophtalmic vein blood flow in glaucoma patients with Phase contrast MRI, preliminary results
Author Affiliations & Notes
  • Veronique Promelle
    Ophthalmology, University Hospital of Amiens, Amiens, France
    Université de Picardie Jules Verne, Amiens, France
  • Solange Milazzo
    Ophthalmology, University Hospital of Amiens, Amiens, France
    Université de Picardie Jules Verne, Amiens, France
  • Gwenael Pagé
    Medical Image Processing Unit, University Hospital of Amiens, Amiens, France
    Université de Picardie Jules Verne, Amiens, France
  • Joel Daouk
    Medical Image Processing Unit, University Hospital of Amiens, Amiens, France
    Université de Picardie Jules Verne, Amiens, France
  • Roger Bouzerar
    Medical Image Processing Unit, University Hospital of Amiens, Amiens, France
    Université de Picardie Jules Verne, Amiens, France
  • Olivier Balédent
    Medical Image Processing Unit, University Hospital of Amiens, Amiens, France
    Université de Picardie Jules Verne, Amiens, France
  • Footnotes
    Commercial Relationships   Veronique Promelle, None; Solange Milazzo, None; Gwenael Pagé, None; Joel Daouk, None; Roger Bouzerar, None; Olivier Balédent, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2996. doi:
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      Veronique Promelle, Solange Milazzo, Gwenael Pagé, Joel Daouk, Roger Bouzerar, Olivier Balédent; Assessment of the ophthalmic artery and the superior ophtalmic vein blood flow in glaucoma patients with Phase contrast MRI, preliminary results. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2996.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : Glaucoma has been proved to be an optic neuropathy with blood flow impairment. Phase contrast magnetic resonance imaging (PC MRI) is an imaging modality able to quantify blood flow in the large orbital vessels. Purpose : Evaluate with PC MRI the potential impairment of the ophthalmic artery (OA) and the superior ophthalmic vein (SOV) blood flow in glaucoma.

Methods : A PC MRI was performed for 6 glaucoma patients and 3 controls on a 3 Tesla MRI. First, a morphological T2-weighed sequence was acquired in order to place a measurement plan perpendicularly to the orbital part of the OA and SOV. The duration of acquisition was less than 2 minutes, allowing to obtain 20 images per cardiac cycle for each vessel. Segmentations of vascular structures were obtained by a dedicated software to calculate blood flow curves. The OA mean, systolic and diastolic flow and the SOV mean flow were automatically calculated.

Results : Glaucoma patients and controls did not show any difference in the mean OA blood flow (23 ± 13 and 19 ± 9 mL/min respectively). The OA systolic flow was increased in patients (48 ± 25 versus 29 ± 11 mL/min for controls) as well as the difference between systolic and diastolic flow during cardiac cycle (37 ± 21 mL/min for patients, 18 ± 4 mL/min for controls). Conversely, the mean venous flow seemed decreased (7 ± 4 mL/min for patients, 11 ± 8 mL/min for controls).

Conclusions : These preliminary results indicate no significant difference in our glaucoma population in OA or SOV mean flows. Glaucoma seems to impact more the pulsatility of the flow during cardiac cycle than the mean blood supply. Numerous factors seem to be involved in glaucoma, including ocular perfusion pressure and translaminar pressure difference. Quantification of the global arterio-venous blood flow of the eye by mean of phase contrast MRI could open new insights on the glaucoma pathology.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Thanks to a plane of acquisition placed perpendicularly to the direction of the ophthalmic artery (OA) or the superior ophthalmic vein (SOV), phase contrast sequence is obtained : 20 images corresponding to 20 phases of a cardiac cycle. The blood flow is calculated for each image and the software provides the curve of the evolution of the flow during an average cardiac cycle for glaucoma and for controls.

Thanks to a plane of acquisition placed perpendicularly to the direction of the ophthalmic artery (OA) or the superior ophthalmic vein (SOV), phase contrast sequence is obtained : 20 images corresponding to 20 phases of a cardiac cycle. The blood flow is calculated for each image and the software provides the curve of the evolution of the flow during an average cardiac cycle for glaucoma and for controls.

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