September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
An Optical Coherence Tomography Angiography Study Of The Iris In Anterior Uveitis
Author Affiliations & Notes
  • Francesco Pichi
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
    Ophthalmology, San Giuseppe Hospital, University Eye Clinic, Bologna, Italy
  • Kimberly Baynes
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Caitlyn Flachbart
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Paolo Nucci
    Ophthalmology, San Giuseppe Hospital, University Eye Clinic, Bologna, Italy
  • Careen Y Lowder
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Sunil K Srivastava
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Francesco Pichi, None; Kimberly Baynes, None; Caitlyn Flachbart, None; Paolo Nucci, None; Careen Lowder, None; Sunil Srivastava, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4624. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Francesco Pichi, Kimberly Baynes, Caitlyn Flachbart, Paolo Nucci, Careen Y Lowder, Sunil K Srivastava; An Optical Coherence Tomography Angiography Study Of The Iris In Anterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4624.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To assess iris vascularization and flow density using optical coherence tomography angiography in a cohort of patients with anterior uveitis.

Methods : One hundred patients with acute anterior uveitis, 100 patients with quiet recurrent anterior uveitis, and 100 normal age-matched subjects were consecutively scanned using a commercially available AngioVue OCTA system (Optovue, Inc., Fremont, CA) and the split-spectrum amplitude decorrelation angiography (SSADA) algorithm. Each subject underwent scans from 4 quadrants (superior, inferior, nasal, and temporal) in each eye by a trained operator. In order to enable blood flow density quantification, a built-in software correlated the SSADA signal at multiple time scales with various preset velocities. For eyes with quiet recurrent anterior uveitis, the time to the following flare up was compared to the iris flow density.

Results : In our study of 100 normal subjects we found good repeatability (k coefficient, 0.71) for flow density assessment of iris vasculature measurements. Iris blood flow density measurements within the regions of interest were compared in the active uveitis group versus the normal patients (temporal iris flow density 76.17% vs 46.44% [P<0.01]; nasal iris blood flow density 72.09% vs 42.06% [P<0.01]). The established OCTA scanning protocol was then used in 100 patients with quiet recurrent anterior uveitis in which a mean iris blood flow density over 55.8% was positively correlated with a reactivation of the inflammation (defined as >1+ anterior chamber cells) within 13.2 days.

Conclusions : This preliminary study describes the acquisition of OCTA images of the iris vasculature and analysis of the iris blood flow density in normal and active uveitis patients. Iris flow density seems to increase consistently with increase degree of inflammation in the anterior chamber. Furthermore, as ciliary flush detected by clinical examination precedes active anterior uveitis, an increased iris flow density seems to be predictive of a reactivation of a quiescent recurrent uveitis.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×