September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Comparative study of aqueous humor dynamics of healthy and uveitis subjects
Author Affiliations & Notes
  • Pouya Alaghband
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
  • Alex Baneke
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
  • Elizabeth Galvis
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
  • Miles R Stanford
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
  • K Sheng Lim
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships   Pouya Alaghband, None; Alex Baneke, None; Elizabeth Galvis, None; Miles Stanford, None; K Sheng Lim, None
  • Footnotes
    Support  Royal Collge of Ophthalmogists research grant
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4677. doi:
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      Pouya Alaghband, Alex Baneke, Elizabeth Galvis, Miles R Stanford, K Sheng Lim; Comparative study of aqueous humor dynamics of healthy and uveitis subjects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4677.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the aqueous production and outflows in patients with recurrent idiopathic anterior uveitis with healthy controls.

Methods : Patients with a history of recurrent idiopathic anterior uveitis (>3 attacks) with or without raised IOP were enrolled. Normal healthy subjects with no ocular problems and IOP at screening < 21mmHg formed the control group. Specifically excluded were patients with active intraocular inflammation, patients with other forms of secondary glaucoma, patients who previously had intraocular or refractive surgery, those on systemic medication which can affect aqueous humor production and those with a history of allergy to fluorescein. Aqueous humor dynamics were assessed by digital Shiotz tonography, fluorophotometry and pneumatonometry.

Results : Twenty one healthy volunteers and 16 patients with uveitis were recruited. The subjects’ characteristics are shown in Table 1 below. The mean intraocular pressure between the two groups was similar (15± 2 mmHg and 15± 2 mmHg; 95% CI= -2.3 to 1.02, p=0.44). The tonographic outflow facility (C) was comparable between two groups (0.24± 0.10 ul/min/mmHg and 0.22± 0.08ul/min/mmHg, 95% CI= -0.08 to 0.04, p= 0.51). The aqueous flow rate was not statistically different between the two groups (2.21± 0.7 ul/min and 2.43± 0.8ul/min, 95% CI= -0.30 to 0.73, p= 0.40). Uveoscleral outflow was calculated using Goldmann’s equation with an assumed episcleral venous pressure of 8, 9, 10 or 11 mmHg.
Ft = C (IOP – Pv) + Fu
Therefore: Fu = Ft – C (IOP – Pv)

Conclusions : There is no statistically difference in aqueous humor dynamics in healthy and uveitis with normal IOP subjects. However, more study is needed to investigate the aqueous humor dynamics in uveitis with raised IOP subjects.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Subjects characteristics

Subjects characteristics

 

Aqueous humor dynamics of all subjects

Aqueous humor dynamics of all subjects

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