September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Anatomic correlations between optical coherence tomography angiography microvasculature defects and ganglion cell analysis thinning in glaucomatous and non-glaucomatous optic neuropathy
Author Affiliations & Notes
  • Brandon James Wong
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Rohit Varma
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Vivek Patel
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Dara West
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Carmen A Puliafito
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Amir H Kashani
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Grace Richter
    Ophthalmology, University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Brandon Wong, Carl Zeiss Meditec (F); Rohit Varma, Carl Zeiss Meditec (F); Vivek Patel, Carl Zeiss Meditec (F); Dara West, Carl Zeiss Meditec (F); Carmen Puliafito, Carl Zeiss Meditec (F); Amir Kashani, Carl Zeiss Meditec (F); Grace Richter, Carl Zeiss Meditec (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5465. doi:
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    • Get Citation

      Brandon James Wong, Rohit Varma, Vivek Patel, Dara West, Carmen A Puliafito, Amir H Kashani, Grace Richter; Anatomic correlations between optical coherence tomography angiography microvasculature defects and ganglion cell analysis thinning in glaucomatous and non-glaucomatous optic neuropathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5465.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This prospective, observational case series of patients with primary open angle glaucoma (POAG) and non-glaucomatous optic neuropathy (NGON) characterized qualitative anatomic correlations between optical coherence tomography angiography (OCTA) macular perfusion defects and OCT ganglion cell analysis (GCA) thinning.

Methods : 11 eyes of 7 patients with POAG and 6 eyes from 4 patients with NGON underwent 3x3mm and 6x6mm macular scans by a spectral-domain OCTA prototype device and GCA (ganglion cell layer + inner plexiform layer) macula scans by Cirrus SD-OCT (both Carl Zeiss Meditec, Dublin, CA, USA). Areas of impaired perfusion on OCTA were compared to areas of GCA thinning on OCT.

Results : All images used were good quality scans. Mean age of POAG patients was 66 years, and mean GCA thickness was 71 μm. 4 eyes had superior thinning, 1 had inferior thinning, 1 had superior and inferior thinning, 2 had global thinning, and 3 had non-specific defects on GCA thickness map. OCTA macular microvasculature defects were correlated with GCA thinning in 3 POAG eyes that had the most severe GCA thinning (1 had focal and 2 had global defects). (Fig 1)

Mean age of NGON patients was 53 years, and mean GCA thickness was 61.5 μm. 3 eyes had focal GCA thinning, and 3 had global GCA thinning. Qualitative anatomic correlations between OCTA macular microvasculature defects and GCA thinning were correlated in the 3 NGON eyes with focal defects - 2 of which had ischemic ON and 1 with inflammatory ON. (Fig 2)

Conclusions : OCTA macular perfusion defects showed visually apparent anatomic correlations with GCA thinning in the POAG eyes with advanced GCA thinning. In NGON, these correlations were seen in eyes with focal defects, which included both of the only two ischemic ON cases. OCTA perfusion defects are most apparent in eyes with severely thinned GCA and focal GCA thinning. The correlations were more pronounced in NGON compared to POAG. Larger quantitative studies are needed to determine how well OCTA microvasculature defects correlate with GCA thinning.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

OCT and OCTA images in representative glaucoma patient. Macular perfusion defect and GCA thinning both seen inferotemporally.

OCT and OCTA images in representative glaucoma patient. Macular perfusion defect and GCA thinning both seen inferotemporally.

 

OCT and OCTA images in ischemic optic neuropathy. Macular perfusion defect and GCA thinning both seen superiorly.

OCT and OCTA images in ischemic optic neuropathy. Macular perfusion defect and GCA thinning both seen superiorly.

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