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Hidenaga Kobashi, Kazutaka Kamiya, Akihito Igarashi, Kimiya Shimizu; Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):633.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the factors affecting corrected distance visual acuity (CDVA) in patients with Fuchs' endothelial corneal dystrophy (FECD).
We retrospectively examined 31 eyes of 21 consecutive patients (age, 68.5±11.2 years [mean ± standard deviation]) with patients with FECD. Stepwise multiple regression analysis was used to assess the factors affecting the CDVA.
The mean logMAR CDVA, endothelial cell density (ECD), central corneal thickness (CCT), corneal astigmatism, objective scattering index (OSI), corneal density, and corneal higher-order aberrations (HOAs) was 0.08±0.22, 1892±590 /mm2, 572±52 μm, 1.52±1.26 diopters, 6.60±4.30, 24.41±7.78, and 0.35±0.19 μm, respectively. Explanatory variables relevant to the CDVA were, in order of influence, OSI (partial regression coefficient B=0.037, p<0.001) and corneal density (B=0.009, p=0.035) (adjusted R2=0.694). Multiple regression was expressed by the following equation: CDVA=(0.037×OSI)+(0.009×corneal density)-0.843. No significant correlation was seen with other clinical factors such as age, ECD, CCT, corneal astigmatism, or corneal HOAs. Similar results were obtained by Spearman rank correlation test (Figure 1 and Figure 2).
Eyes with higher light scattering, especially higher forward light scattering are more predisposed to show deteriorated visual acuity. Intraocular forward light scattering can be useful to evaluate the visual performance and determine the surgical indications of endothelial keratoplasty for eyes with FECD.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
Figure 1. A graph showing a significant correlation between the corrected distance visual acuity and the objective scattering index (Spearman correlation coefficient r=0.779, p<0.001).
Figure 2. A graph showing a significant correlation between the corrected distance visual acuity and the corneal density (Spearman correlation coefficient, r=0.412, p=0.021).
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