September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Magnetic Resonance Angiography of the Choroid in Patients with Age-Related Macular Degeneration
Author Affiliations & Notes
  • Gina Yu
    Dept of Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Weiying Dai
    Dept of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Lauren O'Loughlin
    Dept of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Li Zhao
    Dept of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Eli Levitt
    Dept of Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Aria Bassiri
    Dept of Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Sushant Wagley
    Dept of Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
    Michigan State University, Lansing, Michigan, United States
  • Kyle V Marra
    Dept of Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
    University of California, San Diego, San Diego, California, United States
  • David Alsop
    Dept of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Jorge G Arroyo
    Dept of Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Gina Yu, None; Weiying Dai, None; Lauren O'Loughlin, None; Li Zhao, None; Eli Levitt, None; Aria Bassiri, None; Sushant Wagley, None; Kyle Marra, None; David Alsop, General Electric Healthcare (F), General Electric Healthcare (P), Hitachi (P), Philips (P); Jorge Arroyo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1673. doi:
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    • Get Citation

      Gina Yu, Weiying Dai, Lauren O'Loughlin, Li Zhao, Eli Levitt, Aria Bassiri, Sushant Wagley, Kyle V Marra, David Alsop, Jorge G Arroyo; Magnetic Resonance Angiography of the Choroid in Patients with Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1673.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate significant differences in choroidal perfusion rates in patients with age-related macular degeneration (AMD) compared to age-matched control patients via magnetic resonance angiography (MRA). Techniques to understand choroidal perfusion through laser Doppler have been successfully used but are limited in the scope of measurements taken simultaneously. MRA allows for global, real-time analysis of choroidal blood flow, ensuring a more comprehensive understanding of perfusion in patients.

Methods : This prospective, observational study examined eighteen subjects aged 71 to 90 years, divided into five groups: control volunteers (12 eyes, 6 patients), mild dry (5 eyes, 3 patients), moderate dry (7 eyes, 4 patients), severe dry (6 eyes, 4 patients), and wet AMD (6 eyes, 4 patients). A non-contrast enhanced brain MRA was taken for each subject and choroidal perfusion was measured using an arterial spin labeling (ASL) technique. ASL images were co-registered with anatomical images, and then regions of interest were drawn around the choroid of each eye. To test for significant differences in blood flow, a paired t-test was used between controls and patients.

Results : Mean choroidal blood flow was significantly reduced in AMD patients when averaged together compared to controls (mean reduction [MR] of 30.6%, p<0.01). Significance was also found in mild dry (MR of 39.9%, p = 0.02), severe dry (MR of 39.2%, p=0.02), and wet AMD (MR of 31.2%, p=0.03) compared to controls. Moderate dry AMD blood flow compared to controls was not found to be significant (MR of 16.2%, p=0.18).

Conclusions : AMD patients had significantly reduced blood flow rates compared to age-matched controls when analyzed by MRA. This finding could provide important insight in AMD treatment research and demonstrates the efficacy of MRA in evaluating risk of AMD or other disorders with similar pathogeneses.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Fig. 1. The mean ASL image and reference image from an AMD patient (left eye: mild dry, right eye: wet) and a normal control.

Fig. 1. The mean ASL image and reference image from an AMD patient (left eye: mild dry, right eye: wet) and a normal control.

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