September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Assessment of Reproducibility and Correlation of two SPECTRALIS ® SD OCT Modules for RNFL Thickness measurements and diagnostic Reliability of ONH measurements with SD OCT Glaucoma Module Premium Edition in glaucoma patients and healthy controls
Author Affiliations & Notes
  • Marita Awe
    University Eye Hospital Hannover Medical School, Hannover, Germany., Hannover, Germany
  • Pascal Buley
    University Eye Hospital Hannover Medical School, Hannover, Germany., Hannover, Germany
  • Carsten Framme
    University Eye Hospital Hannover Medical School, Hannover, Germany., Hannover, Germany
  • Shaghayegh Khalili Amiri
    University Eye Hospital Hannover Medical School, Hannover, Germany., Hannover, Germany
  • Katerina Hufendiek
    University Eye Hospital Hannover Medical School, Hannover, Germany., Hannover, Germany
  • Footnotes
    Commercial Relationships   Marita Awe, None; Pascal Buley, None; Carsten Framme, None; Shaghayegh Khalili Amiri, None; Katerina Hufendiek, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 866. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Marita Awe, Pascal Buley, Carsten Framme, Shaghayegh Khalili Amiri, Katerina Hufendiek; Assessment of Reproducibility and Correlation of two SPECTRALIS ® SD OCT Modules for RNFL Thickness measurements and diagnostic Reliability of ONH measurements with SD OCT Glaucoma Module Premium Edition in glaucoma patients and healthy controls. Invest. Ophthalmol. Vis. Sci. 2016;57(12):866.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To assess reproducibility and correlation of SPECTRALIS® SD-OCT and SD OCT Glaucoma Module Premium Edition (APS Module) for RNFL thickness (RNFLT) measurements. It was previously shown that BMO-MRW (Bruch’s membrane opening-minimum rim width-minimum distance between BMO and inner limiting membrane) was a better measure for detecting glaucomatous damage than peripapillary RNFLT. We assessed diagnostic reliability of BMO-MRW with SD OCT APS Module in glaucoma patients and healthy controls.

Methods : Retrospective study of 81 eyes (41 patients) with glaucoma and 49 eyes of 26 healthy controls.Scans were obtained using SPECTRALIS®SD OCT (Heidelberg Engineering, Heidelberg Germany ).In the first analysis RNFLT in each sector was measured with both modules and compared using Pearson coefficient of correlation.
In the second analysis BMO-MRW was assessed by SD OCT APS Module. Sensitivity, specificity and Area under Receiver Operating Characteristics curve (AUROC) of each sector of the optic nerve were calculated using DeLong`s et al. method. Those were compared and statistical significance (p<0.05) was computed.

Results : The first analysis showed a positive correlation (Pearson, 0.618-0.973, p<0.0001) between peripapillary RNFLT measurements by standard SD OCT and all diameters of RNFLT APS Module within all sectors.
In the second analysis, AUROC of RNFLT in standard SD-OCT was 0.736 in the nasal inferior (NI) sector and 0.709 in the temporal (T)sector.The AUROC of BMO-MRW was 0.85 in NI and 0.86 in T. The difference in AUROC was statistically significant (p<0.004,p<0.0018). AUROC of all other sectors did not show a statistically significant difference.
AUROC of BMO-MRW NI, nasal superior (NS), T and temporal superior (TS) sector was significant greater than AUROC of all RNFLT diameters measured with APS Module (p<0.0001-p=0.0494) (Fig.1).
Extended results are shown in Table1 and Fig.1.

Conclusions : RNFLT of both modules showed a positive correlation and the results were reproducible. We found that BMO-MRW in T sector and NI is more sensitive in detecting glaucomatous changes than RNFLT standard SD OCT. The same was observed for BMO-MRW and RNFLT measured with APS module for NI, NS, TS, T sector.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Table1:Extended Results

Table1:Extended Results

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×