September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Significant Difference Between Fractal Dimension of OCT Angiography of Eyes With and Without Nonproliferative Diabetic Retinopathy.
Author Affiliations & Notes
  • Emma Young
    Ophthalmology, New York University , New York, New York, United States
  • Sarwar Zahid
    Ophthalmology, New York University , New York, New York, United States
  • Joshua Young
    Ophthalmology, New York University , New York, New York, United States
  • Kunal Dansingani
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
  • Chandra Bala
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
  • K Bailey Freund
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
  • Lawrence A. Yannuzzi
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
  • Footnotes
    Commercial Relationships   Emma Young, None; Sarwar Zahid, None; Joshua Young, None; Kunal Dansingani, None; Chandra Bala, None; K Bailey Freund, None; Lawrence A. Yannuzzi, None
  • Footnotes
    Support  LuEsther T. Mertz Retinal Research Center and the Macula Foundation Inc.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Emma Young, Sarwar Zahid, Joshua Young, Kunal Dansingani, Chandra Bala, K Bailey Freund, Lawrence A. Yannuzzi; Significant Difference Between Fractal Dimension of OCT Angiography of Eyes With and Without Nonproliferative Diabetic Retinopathy.. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical Coherence Tomography Angiography (OCTA) provides largely qualitative vascular information. We compared quantitatively the retinal fractal dimension in eyes with nonproliferative diabetic retinopathy (NPDR) with control eyes using OCTA.

Methods : A retrospective study was performed of ten eyes with different stages of NPDR without macular edema and six control eyes. OCTA images were obtained using the RTVue XR Avanti (Optovue, Inc., Fremont, CA). Automated segmentation was obtained through the superficial and deep retinal capillary plexuses for each eye. The grayscale OCTA images were standardized, cropped, and converted to black and white using GIMP (GIMP Development, Berkeley, CA). Fractal dimensional box-counting analyses were performed using Fractalyse (ThéMA, Besançon Cedex, France). Fractal dimensions (FD) of superficial and deep capillary plexuses were compared between NPDR and control eyes. Two-tailed t-tests were used to compare the average FD between groups.

Results : The superficial and deep plexuses from six control eyes and ten NPDR eyes were processed and analyzed as described above (Figure 1). The average FD for NPDR eyes (1.5324, SD=0.0210) was significantly lower than control eyes (1.6777, SD=0.0191) for the superficial capillary plexus (p = 1.2078 x 10-8). For the deep capillary plexus, the average FD for NPDR eyes (1.5695, SD=0.05999) was significantly lower than control eyes (1.7833, SD=0.0131) (p = 5.469 x 10-7).

Conclusions : The fractal dimension is significantly lower in both superficial and deep capillary plexuses in NPDR compared to control eyes. Fractal analysis holds the potential to establish quantitative disease parameters for microvascular pathology.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

A: OCTA image of the superficial retinal capillary plexus of a control eye after cropping, standardization and conversion to black and white.
B: OCTA image of the superficial retinal capillary plexus of an NPDR eye after cropping, standardization and conversion to black and white.
C: Fractal analysis of the superficial capillary plexus from a control eye.
D: Fractal analysis of the superficial capillary plexus from an NPDR eye.

A: OCTA image of the superficial retinal capillary plexus of a control eye after cropping, standardization and conversion to black and white.
B: OCTA image of the superficial retinal capillary plexus of an NPDR eye after cropping, standardization and conversion to black and white.
C: Fractal analysis of the superficial capillary plexus from a control eye.
D: Fractal analysis of the superficial capillary plexus from an NPDR eye.

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