September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
One-year outcomes of changes in corneal densitometry after accelerated (45mW/cm2) transepithelial corneal collagen cross-linking for keratoconus
Author Affiliations & Notes
  • Yang Shen
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Weijun Jian
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Ling Sun
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Meng Li
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Tian Han
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Mi Tian
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Xingtao Zhou
    Eye and ENT Hospital of Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships   Yang Shen, None; Weijun Jian, None; Ling Sun, None; Meng Li, None; Tian Han, None; Mi Tian, None; Xingtao Zhou, None
  • Footnotes
    Support  National Natural Science Foundation of China(Grant No.81570879); Outstanding Academic Leaders Program of Shanghai Health System (Grant No. XBR2013098)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2890. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Yang Shen, Weijun Jian, Ling Sun, Meng Li, Tian Han, Mi Tian, Xingtao Zhou; One-year outcomes of changes in corneal densitometry after accelerated (45mW/cm2) transepithelial corneal collagen cross-linking for keratoconus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2890.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The conventional CXL (C-CXL) procedure removes corneal epithelium and increases corneal densitometry. Accelerated transepithelial corneal collagen cross-linking (ATE-CXL) is a newly developed CXL technique, which maintains the integrity of corneal epithelium layer. We investigated the changes in corneal densitometry after ATE-CXL for progressive keratoconus by using an automatic Scheimpflug Densitometry Program.

Methods : Forty eyes of 40 participants including 20 eyes of 20 patients (24.9±6.5 years, 13 male and 7 female) diagnosed with progressive KC (KC group) and 20 eyes of 20 myopic patients (24.9±6.5 years, 13 male and 7 female, Control group) were recruited. Corneal topography and corneal densitometry were evaluated before ATE-CXL and at the 1-, 6-, and 12-month follow-up visits. Manifest refraction spherical equivalent (MRSE) and best-corrected distant visual acuity (BCDVA) were assessed before and at 12-month after the procedure.

Results : MRSE remained stable (t=0.458, P=0.652) but BCDVA improved significantly (Z=-2.857, P=0.004) at 12 months after ATE-CXL. The densitometry values (annulus 0 to 6mm in diameter) of the anterior layer, central layer, posterior layer and the total thickness of the corneas in the KC group were all significantly higher than those in the control group (All P values <0.01). After ATE-CXL procedure, the densitometry values (over the annulus 0 to 2mm area) of the anterior layer (F=4.729, P=0.005), central layer (F=7.960, P<0.001), posterior layer (F=6.622, P=0.001) and total thickness (F=6.551, P=0.001) decreased significantly, as well as over the annulus 2 to 6mm area (F=3.961, P=0.012; F=9.739, P<0.001; F=7.130, P<0.001 and F=6.415, P<0.001,respectively). Although the densitometry values all decreased in the 12 months postoperatively, they were still statistically higher than those of the control group (All P values <0.01).

Conclusions : The densitometry values of progressive KC patients were higher than those of the myopic ones. The main topographic parameters remain stable, but the densitometry values decreased steadily during the first year after ATE-CXL. At 12 months postoperatively, the densitometry values of progressive KC patients remains higher than those of the myopic population.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

Corneal densitometry analysis

Corneal densitometry analysis

 

Riboflavin was saturating the total thickness of the corneal tissue

Riboflavin was saturating the total thickness of the corneal tissue

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×