September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Comparing Optical Coherence Tomography Angiography (OCTA) Radial Peripapillary Capillary Perfusion Density Maps in Glaucoma Patients and Normal Patients.
Author Affiliations & Notes
  • Nicole K Scripsema
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Patricia Garcia
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Luna Xu
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Yijie Lin
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Joseph Panarelli
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Paul A Sidoti
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Richard B Rosen
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York, United States
  • Footnotes
    Commercial Relationships   Nicole Scripsema, None; Patricia Garcia, None; Luna Xu, None; Yijie Lin, None; Joseph Panarelli, None; Paul Sidoti, None; Richard Rosen, Allergan (C), Nano Retina (C), Ocata Medical (C), Opticology (I), Optovue (C), Regeneron (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5509. doi:
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    • Get Citation

      Nicole K Scripsema, Patricia Garcia, Luna Xu, Yijie Lin, Joseph Panarelli, Paul A Sidoti, Richard B Rosen; Comparing Optical Coherence Tomography Angiography (OCTA) Radial Peripapillary Capillary Perfusion Density Maps in Glaucoma Patients and Normal Patients.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5509.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the usefulness of OCTA capillary perfusion density (CPD) maps for detecting differences in the perfusion of radial peripapillary capillaries (RPCs) in patients with glaucoma compared to normal patients.

Methods : A retrospective review of both normal patients and patients with open-angle glaucoma imaged with OCTA was performed. Each patient was imaged using SD-OCT (Avanti RTVue-XR, Optovue, Fremont, CA), obtaining both 3.5mm and 4.5mm peripapillary scans. A single eye of each patient was used for analysis. A split-spectrum amplitude decorrelation angiography (SSADA) algorithm generated en face OCT angiograms that identified RPCs. A customized algorithm generated color-coded CPD maps for qualitative analysis. We compared CPD maps in normal patients and patients with glaucoma. For each patient, CPD maps were compared to OCT Retinal Nerve Fiber Layer Analysis (RNFL, Cirrus HDT-OCT 500, Carl Zeiss Meditech Inc, Dublin, CA).

Results : A total of 66 glaucoma patients and 21 normal patients were included. Mean age was 65.63 ± 9.42 years. Age, gender, and ethnicity were similar across groups. Color-coded CPD maps identified regions of RPC perfusion loss in glaucoma patients when compared to normal patients (Figure 1). Regions of RPC perfusion loss were most commonly seen in the superior and inferior rim. Patients with early glaucoma and normal OCT RNFL analysis demonstrated early RPC perfusion changes. In glaucoma patients with thinning on OCT RNFL analysis, the area of thinning often corresponded with regions of RPC perfusion loss. Patients with advanced glaucoma and greater RNFL thinning demonstrated larger regions perfusion loss compared to patients with early glaucomatous changes.

Conclusions : OCTA is a rapid, non-invasive technique capable of identifying changes in RPC perfusion in glaucoma patients. OCTA may offer benefits of early diagnosis and more precise monitoring of glaucoma patients. Additional investigations are necessary to establish the clinical applications of OCTA in glaucoma management.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

 

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