September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Wide-field MultiColor Spectral Imaging and Wide-field Spectral Domain Optical Coherence Tomography Imaging in ABCA4-related retinal dystrophies
Author Affiliations & Notes
  • Simone Kellner
    AugenZentrum Siegburg. MVZ ADTC Siegburg GmbH, Rare retinal Disease Center, Siegburg, Germany
    RetinaScience, Bonn, Germany
  • Silke Weinitz
    AugenZentrum Siegburg. MVZ ADTC Siegburg GmbH, Rare retinal Disease Center, Siegburg, Germany
    RetinaScience, Bonn, Germany
  • Ghazaleh Farmand
    AugenZentrum Siegburg. MVZ ADTC Siegburg GmbH, Rare retinal Disease Center, Siegburg, Germany
  • Heidi Barbara Stoehr
    Institute for Human Genetics, Regensburg, Germany
  • Bernhard HF Weber
    Institute for Human Genetics, Regensburg, Germany
  • Ulrich Kellner
    AugenZentrum Siegburg. MVZ ADTC Siegburg GmbH, Rare retinal Disease Center, Siegburg, Germany
    RetinaScience, Bonn, Germany
  • Footnotes
    Commercial Relationships   Simone Kellner, None; Silke Weinitz, None; Ghazaleh Farmand, None; Heidi Stoehr, None; Bernhard Weber, None; Ulrich Kellner, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 147. doi:
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      Simone Kellner, Silke Weinitz, Ghazaleh Farmand, Heidi Barbara Stoehr, Bernhard HF Weber, Ulrich Kellner; Wide-field MultiColor Spectral Imaging and Wide-field Spectral Domain Optical Coherence Tomography Imaging in ABCA4-related retinal dystrophies. Invest. Ophthalmol. Vis. Sci. 2016;57(12):147.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To evaluate the diagnostic value of wide-field MultiColor spectral imaging (WF-MC) and wide-field spectral domain optical coherence tomography (WF-SD-OCT) in patients with ABCA4-related retinal dystrophies.

Methods : Between November 2014 and November 2015 a consecutive series of 23 patients with ABCA4-related retinal dystrophies were examined clinically and with WF-MC and WF-SD-OCT (55 degrees, Spectralis MultiColor HRA & OCT, Heidelberg Engineering, Germany)). Further retinal imaging in 30 or 55 degree mode (fundus autofluorescence (FAF), near-infrared autofluorescence (NIA), spectral domain OCT (SD-OCT) were performed with the same system. DNA testing was performed via targeted gene panel diagnostics.

Results : The series of patients included ABCA4-related retinal dystrophies. WF-MC provided a wide-angle view of retinal abnormalities beyond the vascular arcades excluding the far periphery. In the majority of patients lesions were confined to the posterior pole, mid-peripheral lesions indicated progression from macular dystrophy to cone-rod dystrophy. The evaluation of the three different monochromatic images (blue 486 nm, green 518 nm, near-infrared 815 nm) allowed a differentiation in inner retinal or pigment epithelial and choroidal lesions. Subretinal lesions beyond the posterior pole could be visualized with WF-SD-OCT as indicator for cone-rod-dystophy.

Conclusions : WF-MC and WF-SD-OCT provide the opportunity to observe more details of retinal alterations in ABCA4-related retinal dystrophies at the posterior pole and in the peripheral retina visualizing the continuous change of lesions from the fovea to the periphery

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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