September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Aspirin Use and Age-related Macular Degeneration in a multi-ethnic Asian population: the Singapore Epidemiology of Eye Diseases (SEED) Study
Author Affiliations & Notes
  • Yasuo Yanagi
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Yuan Shi
    Singapore Eye Research Institute, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Gemmy Cheung
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Paul Mitchell
    The University of Sydney, Sydney, New South Wales, Australia
  • Jie Jin Wang
    The University of Sydney, Sydney, New South Wales, Australia
  • Tien Yin Wong
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Yasuo Yanagi, None; Yuan Shi, None; Ching-Yu Cheng, None; Gemmy Cheung, None; Paul Mitchell, None; Jie Jin Wang, None; Tien Yin Wong , None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 20. doi:
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    • Get Citation

      Yasuo Yanagi, Yuan Shi, Ching-Yu Cheng, Gemmy Cheung, Paul Mitchell, Jie Jin Wang, Tien Yin Wong; Aspirin Use and Age-related Macular Degeneration in a multi-ethnic Asian population: the Singapore Epidemiology of Eye Diseases (SEED) Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):20.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the association between aspirin intake and age-related macular degeneration (AMD) an adult multiethinic Asian population in Singapore.

Methods : The Singapore Epidemiology of Eye Disease (SEED) Study is a population-based study, comprising three major ethnic groups (Chinese, Malays and Indians) in Singapore. A total of 10,033 individuals 40 years of age or older participated in the study. Participants underwent a comprehensive ocular examination, including dilated fundus photography. AMD signs were graded from retinal images following the modified Wisconsin grading system. Information on aspirin intake was obtained from a standardised questionnaire.

Results : Aspirin use was reported by 7.6 % of participants [Chinese (6.5%), Malays (4.9%) and Indians (11.4%)]. Any AMD were present among 10.9 % of aspirin users and 6.3 % of non-aspirin users (P<0.001). After adjusting for potential confounders, including age, gender, smoking history, blood pressure and ethnicity, aspirin use was not associated with any AMD (OR 1.03; 95% CI: 0.79 to 1.33; P=0.831), early AMD (OR 1.09; 95% CI: 0.83 to 1.42; P=0.517) or late AMD (OR 0.84; 95% CI: 0.23 to 1.33; P=0.252). In stratified analysis, aspirin use was significantly associated with early AMD in Indians (OR 1.53, 95% CI 1.03 to 2.23; P=0.032) but not in Chinese (adjusted OR 0.83; 95% CI 0.50 to 1.32; P=0.447) and Malays (adjusted OR 0.96; 95% CI 0.48 to 1.77; P=0.911), after adjusting for age and gender; however, this association was not observed for any AMD or late AMD.

Conclusions : Aspirin use overall was not associated with AMD. Only a marginal association between aspirin use and early AMD was found in Indians; however, this finding must be considered very cautiously.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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