September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Reference Data for Fixation Stability in Normal Subjects Measured with Bivariate Contour Ellipse Area (BCEA) in MAIA Microperimetry
Author Affiliations & Notes
  • Marco U Morales
    Academic Ophthalmology, Nottingham University, Nottingham, United Kingdom
  • Saker Saker
    Academic Ophthalmology, Nottingham University, Nottingham, United Kingdom
  • Craig Wilde
    Academic Ophthalmology, Nottingham University, Nottingham, United Kingdom
  • Aristophanes Pallikaris
    Institute of Vision and Optics , University of Crete, Heraklion, Greece
  • Neil Notaroberto
    CLEVER Eye Institute, CLEVER Eye Institute, Louisiana, United States
  • Rubinstein Martin
    Academic Ophthalmology, Nottingham University, Nottingham, United Kingdom
  • Michael K Smolek
    CLEVER Eye Institute, CLEVER Eye Institute, Louisiana, United States
  • Winfried M K Amoaku
    Academic Ophthalmology, Nottingham University, Nottingham, United Kingdom
  • Footnotes
    Commercial Relationships   Marco Morales, Centervue (F), Centervue (I), Centervue (C); Saker Saker, None; Craig Wilde, None; Aristophanes Pallikaris, None; Neil Notaroberto, None; Rubinstein Martin, None; Michael Smolek, None; Winfried Amoaku, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 200. doi:
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      Marco U Morales, Saker Saker, Craig Wilde, Aristophanes Pallikaris, Neil Notaroberto, Rubinstein Martin, Michael K Smolek, Winfried M K Amoaku; Reference Data for Fixation Stability in Normal Subjects Measured with Bivariate Contour Ellipse Area (BCEA) in MAIA Microperimetry. Invest. Ophthalmol. Vis. Sci. 2016;57(12):200.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To establish a reference database for fixation stability measured with the Bivariate Contour Ellipse Area (BCEA) metric in a group of normal subjects tested with the Macular Integrity Assessment Microperimetry (MAIA)

Methods : Participants with no history of any visual abnormalities and normal visual acuity (20/20 or better) had microperimetry performed using the Macular Integrity Assessment Microperimetry (MAIA) device. Fixation stability was assessed for the right eye of each participant using fixation indices P1, P2, and BCEAs with proportional values of 63% and 95%. 180 eyes from 196 participants were recruited. All raw data was exported from the MAIA system (MAIA software version 1.7.0) and collected into a Microsoft Excel spreadsheet. Statistical analysis was performed with linear regression and Pearson’s product-moment correlation coefficient. The α level (type I error) was set at 0.05

Results : The average areas of 0.75° (min = 0.03, max = 3.90, SD = 0.75) for BCEA@63%, and 2.25° (min = 0.20°, max = 11.70°, SD = 2.23) for BCEA@95% were found. The average values of P1 and P2 were 96% (min = 76, max = 100, SD = 5.76) and 99% (min = 91, max = 100, SD = 1.37), respectively. The Pearson's product moment test showed an almost perfect correlation index, r = 0.99, between BCEA@63% and BCEA@95%. P1 showed a very strong correlation with BCEA@63%, r = -0.93, as well as with BCEA@95%, r = -0.93. P2 demonstrated a slightly lower correlation with both BCEA@63% and BCEA@95%, r = -0.90 and -0.90 respectively

Conclusions : The single parameter of the BCEA@95% may be taken as accurately reporting fixation stability and serves as a reference database of normal subjects with a cut off area of 2.25°2 ± 2.23°2 in MAIA microperimetry

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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