September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
OCTAVE study : comparison of choroidal neovascularization patterns in optical coherence tomography angiography, fluorescein and indocyanine green angiography in age-related macular degeneration
Author Affiliations & Notes
  • Julie Espenan
    CHU de Poitiers, POITIERS, France
  • Julien Gozlan
    CHU de Poitiers, POITIERS, France
  • Matthieu Marchetti
    CHU de Poitiers, POITIERS, France
  • Michèle Boissonnot
    CHU de Poitiers, POITIERS, France
  • Nicolas Leveziel
    CHU de Poitiers, POITIERS, France
  • Footnotes
    Commercial Relationships   Julie Espenan, None; Julien Gozlan, None; Matthieu Marchetti, None; Michèle Boissonnot, None; Nicolas Leveziel, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 39. doi:
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      Julie Espenan, Julien Gozlan, Matthieu Marchetti, Michèle Boissonnot, Nicolas Leveziel; OCTAVE study : comparison of choroidal neovascularization patterns in optical coherence tomography angiography, fluorescein and indocyanine green angiography in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):39.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare optical coherence tomography angiography (OCTA) to fluorescein angiography (FA) and indocyanine green (ICGA) angiography in patients with active exudative age-related macular degeneration (AMD).

Methods : Interventional, monocentric, cross-sectional study. OCTA, FA and ICGA were performed in exudative AMD patients with types 1, 2 or 4 neovascularization (corresponding respectively to occult and classic neovascular membranes, and to polypoidal vasculopathy) defined on SD-OCT, FA and ICGA. Distinct morphologic parameters of the neovascular membranes were studied on OCTA images (location, presence of a feeding vessel, presence of an anastomotic arcade, of an hypo-intense peri-lesional border, caliber of the neovascular membrane) and were used to classify them into several patterns: tree, dead-tree, glomerular, lasso and fragmented shapes. Primary endpoint was the description of each type of choroidal neovascularization morphology, with OCTA compared to other imaging modalities (FA and ICGA).

Results : A total of 46 eyes from 43 patients with exudative AMD were included in the analyses. In all eyes, the neovascular complex was clearly observed with OCTA. Types 1, 2 and 4 CNV were respectively observed in 34, 10 and 2 eyes. The most common pattern was the glomerular pattern (38% of type 1 CNV and 60% of type 2 CNV, p<0.05). In type 4 CNV the most frequent pattern was the «dead tree» pattern (100%, p<0.05%).

Conclusions : OCTA provides imaging of CNV related to exudative AMD. This study did not identify any differences in OCTA between CNV types as define by SD-OCT, FA and ICGA. Microvascular structures can be delineated accurately and non invasively, suggesting that this approache provides a safer management of patients with exudative AMD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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